For chemists and researchers in the pharmaceutical and fine chemical industries, a deep understanding of the properties of key intermediates is fundamental to successful synthesis and development. 2-Aminoethanesulphonamide Monohydrochloride (CAS 89756-60-5) is one such compound, serving as a critical building block with a distinct set of chemical characteristics. This article aims to explore its properties, synthesis, and common applications.

Chemical Identity and Structure

2-Aminoethanesulphonamide Monohydrochloride is the hydrochloride salt of 2-aminoethanesulphonamide. Its molecular formula is C2H8N2O2S·HCl, with a molecular weight of approximately 160.62 g/mol. It is typically identified by its CAS number 89756-60-5 and EINECS number 289-519-3. The molecule features a sulfonamide group (-SO2NH2) attached to an ethyl chain, which is also substituted with an amino group (-NH2). The presence of the hydrochloride salt form often enhances its solubility and stability.

Key Chemical Properties

Understanding the physical and chemical properties of 2-Aminoethanesulphonamide Monohydrochloride is crucial for its effective use:

• Appearance: It is commonly supplied as a White Crystalline Powder.
• Purity: High purity, often exceeding 99%, is a critical specification, especially for pharmaceutical applications.
• Melting Point: The melting point is typically in the range of 130-135 °C, with observed values often around 132-133.6 °C. This property is indicative of its crystalline structure and purity.
• Solubility: It exhibits slight solubility in water, methanol, and DMSO, and is often heated to improve dissolution in methanol. The hydrochloride form generally enhances water solubility compared to the free base.
• Stability: The compound is generally stable under standard laboratory conditions when stored properly (e.g., sealed and dry at room temperature).

Synthesis and Manufacturing

The synthesis of 2-Aminoethanesulphonamide Monohydrochloride typically involves multi-step chemical reactions. A common route involves the deprotection of protected sulfonamides. For instance, a procedure might involve the deprotection of 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanesulfonamide using hydrazine hydrate, followed by acidification with hydrochloric acid. Manufacturers focus on optimizing these processes to achieve high yields and exceptional purity, ensuring the final product meets stringent quality requirements. If you are looking to purchase this compound, inquiring about the manufacturing process and quality control measures from potential suppliers is recommended.

Applications in Research and Industry

The distinct chemical structure of 2-Aminoethanesulphonamide Monohydrochloride makes it valuable in several fields:

• Pharmaceutical Intermediates: Its primary use is as a key intermediate in the synthesis of sulfonamide-based drugs. These include important classes of pharmaceuticals such as antimicrobials and diuretics.
• Drug Design: The sulfonamide functional group is a common pharmacophore in drug design. Researchers utilize this compound to develop new therapeutic agents, including enzyme inhibitors, by strategically modifying its structure.
• Biochemical Research: It is employed in biochemical studies, for instance, to investigate sulfonamide-protein interactions, contributing to a deeper understanding of biological processes and disease mechanisms.
• Material Science: It can also serve as a precursor for functionalized polymers and chelating agents, showcasing its versatility beyond pharmaceutical applications.

In conclusion, 2-Aminoethanesulphonamide Monohydrochloride is a multifaceted chemical intermediate whose properties are central to advancements in pharmaceuticals and biochemical research. Understanding its chemical profile is the first step for any scientist or procurement manager looking to leverage its potential and purchase it effectively from a reliable manufacturer.