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Understanding the Chemical Properties of Key Antibiotic Intermediates

The efficacy of a pharmaceutical product is intrinsically linked to the quality of its constituent parts. In the synthesis of complex drugs, particularly antibiotics, understanding the detailed chemical and physical properties of each intermediate is crucial for process optimization and final product integrity. This knowledge empowers researchers and production managers to make informed decisions, ensuring the most efficient and successful synthesis pathways.

Let's examine 6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid (CAS 112984-60-8). This compound serves as a pivotal intermediate in the creation of Prulifloxacin, a significant fluoroquinolone antibiotic. Its description as a light yellow to yellow powder provides an immediate visual cue for identification and quality assessment upon receipt. This physical form is indicative of a solid state under standard laboratory conditions, which is advantageous for handling, storage, and precise measurement in manufacturing processes.

From a chemical perspective, the specification of an assay of ≥98.0% highlights the high purity expected and required for pharmaceutical applications. This high purity is critical because it minimizes the potential for impurities carrying through the synthesis, which could compromise the safety or efficacy of the final Prulifloxacin API. Manufacturers who focus on achieving such high assay levels, like ourselves, provide a significant advantage to their clients, reducing downstream purification challenges.

The molecular formula (C16H16FN3O3S) and molecular weight (349.380) are fundamental parameters for stoichiometric calculations in synthesis, ensuring that reactions are carried out with the correct molar ratios. While specific solubility data might vary, intermediates of this nature often exhibit moderate solubility in polar organic solvents like DMSO, which is a common consideration during reaction setup. The reported melting point (215-218 °C with decomposition) provides further critical information for process control, indicating the thermal stability limits of the compound.

For procurement managers and R&D scientists, understanding these properties is key to successful sourcing. When you choose to buy this intermediate from a reputable manufacturer, you are investing in the assurance that these properties have been carefully controlled and verified. We, as a dedicated supplier, provide detailed technical data to support your formulation and synthesis needs. Our commitment extends to offering reliable supply and competitive prices for this essential pharmaceutical building block, enabling you to focus on innovation and production.

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NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;

2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;

3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

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  • A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.

  • A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.

  • A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.

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