The advancement of medical imaging techniques relies heavily on the development of sophisticated chemical agents capable of precise targeting and signal generation. DOTA-NHS Ester (CAS: 170908-81-3) stands out as a pivotal compound in this domain, facilitating the conjugation of targeting molecules with metal ions for enhanced imaging. As a specialized manufacturer and supplier of fine chemicals, we are dedicated to providing the scientific community with a deep understanding of such critical reagents and ensuring their availability. Our high-purity DOTA-NHS Ester, manufactured in China, is engineered for optimal performance in demanding imaging applications.

At its core, DOTA-NHS Ester is a bifunctional linker. The DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) moiety is a macrocyclic chelator known for its exceptional thermodynamic stability and kinetic inertness when complexed with various metal ions. This stability is crucial for in vivo applications, preventing the release of potentially toxic metal ions. The N-hydroxysuccinimide (NHS) ester functional group, conversely, is a highly reactive ester that readily undergoes nucleophilic substitution with primary amine groups. This reaction, typically occurring at physiological pH, forms a stable amide bond, effectively coupling the DOTA chelator to a molecule of interest, such as a peptide, antibody, or small molecule targeting a specific biological pathway.

The chemical properties of DOTA-NHS Ester make it ideal for radiolabeling in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT). By conjugating DOTA-NHS Ester to a targeting vector that binds to specific receptors or biomarkers, researchers can then chelate radioisotopes like Gallium-68 (68Ga) or Copper-64 (64Cu) for PET, or Technetium-99m (99mTc) for SPECT. The resulting radiolabeled conjugate accumulates at the target site, emitting radiation that can be detected by scanners, providing detailed anatomical and functional information about the disease. Professionals looking to buy DOTA-NHS Ester for these imaging applications need a product that guarantees successful and robust chelation and conjugation.

Furthermore, DOTA-NHS Ester's versatility extends to Magnetic Resonance Imaging (MRI). The DOTA group can effectively chelate paramagnetic ions such as Gadolinium (Gd). When a DOTA-Gd complex is conjugated to a targeting agent using the NHS ester, it can act as a contrast agent, significantly improving the signal-to-noise ratio in MRI scans. This targeted approach allows for higher resolution and more specific visualization of tissues and pathologies, aiding in diagnosis and treatment monitoring. The consistent quality offered by a reputable supplier of DOTA-NHS Ester is essential for developing reliable contrast agents.

As a leading manufacturer in China, we are committed to producing DOTA-NHS Ester with exceptional purity and reactivity. We understand that the success of advanced imaging applications hinges on the quality of the chemical reagents used. By choosing us as your supplier, you ensure access to a product that has undergone rigorous quality control, offering a reliable solution for your imaging research and development needs. We invite you to contact us to inquire about purchasing DOTA-NHS Ester and to discuss how our products can support your innovative work.