Custom Manufacturing, Project Outsourcing, your Trusted Partner from China
Tert-butanesulfinamide (CAS 146374-27-8) is a compound of significant interest in organic synthesis, primarily due to its role as a chiral auxiliary. Understanding its synthesis and inherent properties is key to appreciating its value as a fine chemical. NINGBO INNO PHARMCHEM CO.,LTD. is a provider of this important chemical intermediate.
The synthesis of tert-butanesulfinamide typically involves a multi-step process. A common route begins with the oxidation of tert-butyl disulfide to a thiosulfinate, followed by disulfide bond cleavage using a lithium amide. Alternatively, tert-butyl sulfinic acid can be converted to tert-butyl sulfinyl chloride using thionyl chloride, which is then reacted with ammonia to yield tert-butanesulfinamide. These synthetic routes are well-established, allowing for reliable production. The resulting compound is generally obtained as a white to tan crystalline powder, with a melting point typically around 97-101 °C.
Key properties that make tert-butanesulfinamide valuable include its stability and reactivity profile. It is more resistant to hydrolysis than many other imine derivatives, providing greater flexibility during synthetic manipulations. Simultaneously, it remains sufficiently reactive towards a range of nucleophiles, facilitating diastereoselective addition reactions. The presence of the tert-butyl group provides steric bulk, which is often important in directing the stereochemical outcome of these reactions. Its solubility in common organic solvents like methanol further enhances its ease of use in laboratory settings.
The combination of its well-defined synthesis, favorable chemical properties, and critical role in asymmetric synthesis makes tert-butanesulfinamide a sought-after fine chemical. NINGBO INNO PHARMCHEM CO.,LTD. ensures that its supply of tert-butanesulfinamide meets the high standards required for pharmaceutical research and development, contributing to the advancement of chemical synthesis.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
