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Topoisomerase I (Top1) is a vital enzyme that regulates DNA topology during essential cellular processes like replication, transcription, and recombination. By inducing transient single-strand breaks in DNA and allowing them to reseal, Top1 prevents DNA tangling and supercoiling. This makes it an attractive target for cancer therapy, as inhibiting its function can lead to catastrophic DNA damage in rapidly dividing cancer cells. NINGBO INNO PHARMCHEM CO.,LTD. provides critical pharmaceutical intermediates, such as Belotecan Hydrochloride, that are designed to target this enzyme effectively.
Belotecan Hydrochloride (CKD-602) is a prime example of a Topoisomerase I inhibitor. As a semi-synthetic camptothecin derivative, it functions by stabilizing the cleavable complex formed between Top1 and DNA. This stabilization prevents the resealing of DNA breaks, leading to an accumulation of DNA damage. This damage triggers cell cycle arrest and ultimately programmed cell death (apoptosis) in cancer cells, showcasing its potent antitumor properties. Studies have demonstrated its efficacy in preclinical models and early clinical trials for various cancers.
The development of effective Topoisomerase I inhibitors is an ongoing area of research, with new derivatives constantly being explored. NINGBO INNO PHARMCHEM CO.,LTD. supports this research by supplying high-purity pharmaceutical intermediates. For scientists and pharmaceutical companies looking to purchase Belotecan Hydrochloride to further investigate its therapeutic potential or develop new drug formulations, NINGBO INNO PHARMCHEM CO.,LTD. offers a reliable and quality-assured source. Their commitment to providing essential chemical building blocks is crucial for advancing cancer treatment strategies.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
