For those in the pharmaceutical research and development sector, understanding the properties and applications of key chemical intermediates is crucial for successful synthesis and formulation. Ufiprazole, identified by its CAS number 73590-85-9, is a significant compound within this domain, primarily recognized for its role as an intermediate in the manufacturing of proton pump inhibitors (PPIs), such as Omeprazole and Esomeprazole. This article delves into the chemical characteristics, applications, and procurement considerations for Ufiprazole, offering valuable insights for scientists and procurement professionals alike.

Chemical Profile of Ufiprazole

Ufiprazole, also known chemically as Omeprazole sulfide, possesses the molecular formula C17H19N3O2S and a molecular weight of approximately 329.42 g/mol. It typically appears as a white powder, a common characteristic for high-purity pharmaceutical intermediates. Its chemical structure, a benzimidazole derivative, is specifically designed to be a precursor in the complex synthesis pathways leading to the active pharmaceutical ingredients (APIs) of Omeprazole and Esomeprazole. These PPIs are widely used globally to treat conditions related to excessive stomach acid production.

The Critical Role in PPI Synthesis

The primary utility of Ufiprazole lies in its function as a direct intermediate in the manufacturing processes of Omeprazole and Esomeprazole. The synthetic routes for these blockbuster drugs involve carefully controlled chemical reactions, and Ufiprazole is a critical component that ensures the correct molecular architecture is built step-by-step. Pharmaceutical companies that buy Ufiprazole are investing in a quality raw material that directly impacts the yield, purity, and ultimately, the efficacy of the final therapeutic product. Research scientists often utilize Ufiprazole in laboratory settings to develop novel synthetic routes or to study the metabolic pathways of PPIs.

Sourcing and Quality Considerations for Ufiprazole

When procuring Ufiprazole (CAS 73590-85-9), attention to quality and purity is paramount. Pharmaceutical-grade Ufiprazole typically requires a minimum purity of 99%, with suppliers providing detailed analytical data, such as HPLC chromatograms and mass spectrometry reports, to confirm this. Manufacturers and suppliers in China are often a go-to source for such intermediates, offering competitive pricing and significant production capacity. It is advisable for buyers to request samples, compare prices from multiple Ufiprazole suppliers, and verify their manufacturing standards and certifications to ensure a reliable and high-quality supply chain.

Market Insights and Procurement Advice

For those seeking to purchase Ufiprazole, understanding its market availability and pricing is key. Bulk orders often command better pricing per kilogram. It is beneficial to establish relationships with established chemical manufacturers who specialize in pharmaceutical intermediates. These partnerships can lead to better pricing, consistent supply, and technical support. As a critical component for widely used medications, Ufiprazole remains in consistent demand, making it a staple for many pharmaceutical ingredient suppliers.

In summary, Ufiprazole (CAS 73590-85-9) is an indispensable intermediate in the pharmaceutical industry, particularly for the synthesis of Omeprazole and Esomeprazole. A thorough understanding of its chemical properties and a strategic approach to sourcing from reliable manufacturers, especially those in China, are essential for ensuring product quality and maintaining a robust supply chain.