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The quest for novel molecular structures with tailored properties is a driving force in the chemical industry. Among the most effective strategies for constructing complex organic molecules, particularly nitrogen-containing heterocycles, is the [3+2] cycloaddition reaction. This powerful synthetic tool relies on the controlled combination of a 1,3-dipole and a dipolephile. In this context, N-[(Trimethylsilyl)methyl]benzylamine emerges as a highly valuable reagent, serving as a readily available source of non-stabilized azomethine ylides.
These azomethine ylides, generated in situ from N-[(Trimethylsilyl)methyl]benzylamine under various catalytic conditions (such as trifluoroacetic acid or cesium fluoride), are exceptionally versatile 1,3-dipoles. Their reactivity profile allows them to participate in cycloaddition reactions with a broad spectrum of dipolarophiles, including activated alkenes, aldehydes, and even more exotic substrates like vinyl sulfonyl fluorides and alkenyl boropinacolates. The resulting five-membered nitrogen heterocycles are prevalent in numerous biologically active molecules.
The strategic advantage of using N-[(Trimethylsilyl)methyl]benzylamine lies not only in its ability to generate the reactive ylide but also in the control it offers over stereochemistry. The reaction demonstrates complete cis stereoselectivity with chain olefins, preserving the relative configuration of the starting materials. This precision is critical for synthesizing enantiomerically pure compounds, a prerequisite for many modern pharmaceuticals. The ability to precisely build these complex structures significantly impacts the efficiency of drug discovery and development processes.
For researchers and chemical manufacturers, sourcing high-quality N-[(Trimethylsilyl)methyl]benzylamine is key to unlocking these synthetic possibilities. Understanding the market for this chemical, including where to purchase it and its price, is essential for project planning. The accessibility and reliable reactivity of N-[(Trimethylsilyl)methyl]benzylamine make it an indispensable component in the toolkit of synthetic organic chemists aiming to push the boundaries of molecular design. Its contribution to the synthesis of pyrrolidines and other complex scaffolds underscores its importance in advancing chemical innovation.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
