In the dynamic landscape of pharmaceutical development, certain chemical compounds stand out for their versatility and critical role in synthesizing advanced medicinal agents. Among these, 1-Boc-3-azetidinone, also known by its chemical name tert-Butyl 3-oxoazetidine-1-carboxylate, emerges as a compound of significant importance. With the Chemical Abstracts Service (CAS) number 398489-26-4, this intermediate is a cornerstone in the production of various pharmaceuticals, embodying a fusion of precision chemistry and therapeutic innovation.

1-Boc-3-azetidinone boasts a molecular formula of C8H13NO3 and a molecular weight of 171.194. Its physical characteristics include an appearance as off-white crystals, indicative of its purity and stability. Key physical and chemical properties further define this compound: it has a melting point typically ranging from 49 to 52°C, a boiling point estimated at 251.3±33.0°C at 760 mmHg, and a density of approximately 1.2 g/cm3. The flash point for this compound is around 105.8±25.4°C. These properties ensure its safe handling and effective application in various synthetic processes.

The primary application of 1-Boc-3-azetidinone lies in its role as a crucial intermediate in the synthesis of high-value pharmaceutical compounds. Most notably, it is a key precursor for Baricitinib, a potent Janus kinase (JAK) inhibitor used in the treatment of various inflammatory and autoimmune disorders, including rheumatoid arthritis and alopecia areata. Its significance extends beyond Baricitinib, serving as a pivotal building block for a diverse range of therapeutic agents.

Beyond Baricitinib, tert-Butyl 3-oxoazetidine-1-carboxylate is integral in preparing a wide array of other medicaments. It is utilized in the synthesis of novel antibacterial aminoglycoside analogs, contributing to the development of new treatments against bacterial infections. Furthermore, this compound plays a role in the creation of second-class HCV protease inhibitors, vital for combating Hepatitis C virus genotype 1 infection. Research also indicates its utility in developing bicyclic himbacine derivatives, which act as antagonists of protease-activated receptor-1 (PAR-1) and are explored for treating acute coronary syndrome, myocardial infarction, and thrombotic stroke. Additionally, it aids in the synthesis of bicyclic azacyclobenzylamine derivatives, such as pyridopyrimidines, which modulate the activity of phospho-inositol 3-kinase (PI3K) and are relevant in treating various inflammatory disorders, immune-based conditions, and certain cancers.

NINGBO INNO PHARMCHEM CO.,LTD. specializes in the production and supply of high-purity 1-Boc-3-azetidinone, ensuring an assay purity of ≥98.0%. Our product is carefully packaged in 25 kg drums, with flexible packaging options available to meet specific customer requirements. For optimal preservation of its quality and stability, it is recommended to store 1-Boc-3-azetidinone in a cool, well-ventilated place, ideally at a temperature range of 2-8°C, given its moisture-sensitive nature.

As a leading manufacturer and reliable supplier, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing top-quality tert-Butyl 3-oxoazetidine-1-carboxylate to global pharmaceutical companies and research institutions. We offer competitive price and efficient delivery services, ensuring that our clients can confidently buy or purchase this essential intermediate. Our dedicated team is ready to assist with any inquiries and facilitate your procurement needs for this vital compound in the chemical industry.