Benserazide hydrochloride, commonly known as Benserazide HCl, with its unique Chemical Abstracts Service (CAS) number 14919-77-8, stands as a pivotal compound in the pharmaceutical landscape. This active pharmaceutical ingredient (API) is primarily recognized for its indispensable role in the comprehensive treatment strategies for Parkinson's disease. Its chemical profile, coupled with its specific inhibitory actions, makes it an invaluable asset in improving the quality of life for patients globally.

Chemically, Benserazide hydrochloride presents as a white solid powder. Its molecular formula is C10H16ClN3O5, contributing to a molecular weight of approximately 293.7 g/mol. Key physical properties include a melting point typically ranging from 146°C to 148°C. In terms of solubility, it is readily soluble in water, dimethyl sulfoxide (DMSO), and methanol, while showing insolubility in ethanol and acetone. These characteristics are critical for its formulation and efficacy in various pharmaceutical preparations.

The therapeutic significance of Benserazide hydrochloride primarily stems from its function as a peripheral decarboxylase inhibitor. In Parkinson's disease, there is a deficiency of dopamine in specific brain regions. Levodopa, a precursor to dopamine, is often prescribed to replenish these levels. However, if administered alone, a significant portion of levodopa would be converted into dopamine in the periphery (outside the brain) before it can reach the central nervous system. This peripheral conversion not only reduces the amount of levodopa available to the brain but also leads to undesirable side effects such as nausea, vomiting, and cardiovascular issues.

This is where Benserazide HCl plays its crucial role. As a decarboxylase inhibitor, it prevents the enzyme L-aromatic amino acid decarboxylase (AADC) from converting levodopa into dopamine in the body's peripheral tissues. By inhibiting this process, Benserazide hydrochloride ensures that a much larger proportion of the administered levodopa crosses the blood-brain barrier intact. Once inside the brain, this increased concentration of levodopa can then be effectively converted into dopamine, leading to a more potent and targeted therapeutic effect. This synergistic action, typically seen in combination therapies like co-beneldopa (Madopar), significantly enhances the benefits of levodopa, allowing for lower doses and a reduction in levodopa-related peripheral side effects. Patients often experience marked improvements in motor symptoms such as stiffness, tremors, and slowness of movement, thereby vastly improving their daily functionality and overall well-being.

Beyond its primary application in Parkinson's treatment, Benserazide hydrochloride also serves as an inhibitor for tyrosine hydroxylase (TH) and Tryptophan hydroxylase (TPH), two other important enzymes in metabolic pathways. Its broad utility as a decarboxylase inhibitor makes it a valuable compound for various research and development efforts in the pharmaceutical industry, extending its potential applications.

For pharmaceutical manufacturers and researchers, ensuring the consistent supply of high-purity Benserazide hydrochloride is paramount. Quality assurance protocols, including stringent analytical testing for purity, identity, and absence of impurities, are critical to meet the rigorous standards of the pharmaceutical industry. Reliable suppliers understand the importance of maintaining excellent storage conditions—typically in a well-closed, light-resistant, dry, and cool environment (2-8°C)—to preserve the integrity and efficacy of the compound.

When considering the procurement of Benserazide hydrochloride, it is essential to partner with a reputable manufacturer and supplier who can provide comprehensive product documentation and adhere to global regulatory standards. Factors such as competitive price, robust supply chain management, and scalable production capabilities are vital for ensuring uninterrupted pharmaceutical production. Whether you are looking to buy for large-scale production or for research and development purposes, inquiries about Benserazide hydrochloride (CAS 14919-77-8) should be directed to experienced chemical companies committed to quality and reliability. We strive to offer unparalleled support and transparent information for your purchase requirements, ensuring your access to this crucial API. Our dedication as a leading manufacturer in the field emphasizes providing a consistent and high-quality supply to meet the evolving demands of the global pharmaceutical market.