Copovidone, also known as PVP VA64, is a highly versatile copolymer derived from N-vinyl-2-pyrrolidone and vinyl acetate. Identified by CAS number 25086-89-9, this fine chemical material is predominantly supplied in powder form and is recognized for its environmental friendliness and wide range of applications across various industries. As a non-ionic polymer, Copovidone offers excellent solubility in both water and a variety of organic solvents, making it a flexible choice for formulators.

The unique properties of Copovidone stem from the controlled copolymerization of its constituent monomers. The ratio of vinylpyrrolidone to vinyl acetate in the polymer chain can be adjusted, leading to different grades such as VA64, VA73, and VA37, each exhibiting slightly different characteristics, particularly in terms of hygroscopicity and flexibility. The VA64 grade, with its balanced composition, is particularly favored for its optimal performance in numerous applications. Physically, Copovidone PVP VA64 presents as a white to slightly yellowish powder, characterized by its free-flowing nature and high purity, typically >=95%.

In the pharmaceutical sector, Copovidone PVP VA64 plays a crucial role as a multi-functional excipient. Its primary use is as a dry binder and wet granulation binder in tablet manufacturing. It effectively agglomerates powder particles, improving flow properties and compressibility, which are essential for direct compression and wet granulation processes. This results in tablets with enhanced mechanical strength, reduced friability, and improved uniformity. Furthermore, Copovidone serves as an excellent film-forming agent for tablet coatings, providing a smooth, uniform layer that can protect the core from moisture and light, mask unpleasant tastes or odors, and aid in swallowability. Its good adhesion properties ensure the film adheres well to the tablet surface.

Beyond its role as a binder and film-former, Copovidone is also utilized in pharmaceutical formulations as a matrix former in solid dispersion technologies to enhance the solubility and bioavailability of poorly soluble active pharmaceutical ingredients (APIs). Its ability to interact with hydrophobic drug molecules and stabilize amorphous forms contributes significantly to improved drug delivery systems. Compliance with stringent quality standards such as USP, EP/BP, and certifications like GMP and DMF are imperative for its use in pharmaceutical applications, ensuring safety and efficacy.

The cosmetic industry extensively utilizes Copovidone PVP VA64 for its film-forming and hair-fixing capabilities. In hair care products like sprays, gels, mousses, and lotions, it forms a clear, non-tacky film on the hair shaft, providing hold, style retention, and body without excessive stiffness. The varying vinyl acetate content influences the film's flexibility and resistance to humidity, allowing formulators to tailor product performance. Its good solubility in water and alcohol blends facilitates easy application and removal. In skincare and makeup, Copovidone can act as a film-former, improving product longevity and feel, or as a viscosity modifier and emulsion stabilizer.

Copovidone's utility extends to various other industrial applications. It is a valuable component in adhesive formulations, particularly in remoistenable adhesives and hot-melt adhesives, where its binding strength and film-forming properties are advantageous. In the field of coatings and paints, it functions as a protective colloid and binder, improving pigment dispersion, film integrity, and adhesion to substrates. Its application in printing inks enhances pigment dispersion and viscosity control, leading to improved print quality. Furthermore, it finds use as a dispersing agent or binder in specialized applications such as plant-protecting chemicals and textile processing.

The quality specifications for Copovidone PVP VA64 are rigorously defined in pharmacopoeias and technical standards. Key parameters include K-Value, which indicates the molecular weight and affects viscosity and binding strength; pH; content of vinyl acetate and residual vinylpyrrolidinone; moisture content; and limits for heavy metals and microbial contaminants. These tests ensure the product's suitability and safety for its intended uses across different grades and applications.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying high-quality Copovidone (PVP VA64) powder meeting global standards. As a reliable manufacturer and supplier of fine chemical materials, we ensure our Copovidone production adheres to strict quality control protocols and relevant certifications, including GMP, Kosher, and Halal. Our commitment to quality guarantees product consistency and performance for our customers worldwide. The product is typically packaged in 25kg fiber drums, offering convenient handling and storage with a standard shelf life of 3 years.

For companies seeking a dependable source of Copovidone PVP VA64 powder for pharmaceutical, cosmetic, or other industrial applications, NINGBO INNO PHARMCHEM CO.,LTD. offers competitive options. We welcome inquiries from businesses looking to buy or purchase this versatile polymer in various quantities, starting from a minimum order quantity (MOQ) of 25kg. Detailed information regarding product specifications, sample availability, and current market price can be obtained by contacting our sales team. We are poised to serve as your trusted supplier for high-quality Copovidone, facilitating smooth transactions and reliable logistics for your purchase needs.