Dinoprost, also widely known as Prostaglandin F2 alpha (PGF2α), stands as a vital and versatile active pharmaceutical ingredient (API) in the global healthcare market. Identified by its Chemical Abstracts Service (CAS) number 551-11-1, this compound is a naturally occurring prostaglandin derivative with profound effects on reproductive physiology across various species, including humans and a wide range of animals. Its availability as a high-purity raw material, typically in a white powder form, is essential for the manufacture of various therapeutic products.

Prostaglandins are lipid compounds derived enzymatically from fatty acids, playing crucial roles in numerous bodily processes. PGF2α, in particular, is synthesized in many tissues and exerts its effects by binding to specific prostaglandin F2 alpha receptors. While its physiological functions are diverse, its most clinically significant actions relate to smooth muscle contraction and luteolysis, which is the regression of the corpus luteum. The corpus luteum is a temporary endocrine gland that produces progesterone, a hormone essential for maintaining pregnancy. By causing the demise of the corpus luteum, Dinoprost leads to a sharp decline in progesterone levels, which is the basis for many of its therapeutic applications.

In human medicine, Dinoprost has been employed for several critical applications, particularly in obstetrics and gynecology. One primary use is the induction of labor in term pregnancies, helping to initiate contractions and facilitate delivery when medically necessary. It is also utilized for therapeutic abortion, especially in the mid-gestation period (typically 16 to 20 weeks), or in cases involving fetal death in utero or significant congenital malformations where termination is indicated. The mechanism involves stimulating uterine muscle contractions. Additionally, it has seen use as a vasodilator in specific medical procedures, such as angiography, although this application is less common than its reproductive roles.

However, the impact of Dinoprost as an API is perhaps most pronounced in the veterinary sector. Known widely under various brand names for veterinary use, Dinoprost is indispensable for managing reproductive cycles and treating conditions in livestock such as cattle, horses, and pigs. Its potent luteolytic action is the cornerstone of its veterinary applications. It is extensively used for estrus synchronization, a technique that allows producers to bring a group of female animals into heat simultaneously. This is invaluable for timed artificial insemination programs, improving breeding efficiency and management logistics on farms and ranches. Synchronized breeding cycles lead to more predictable calving, foaling, or farrowing periods, optimizing labor and facility use. Furthermore, Dinoprost is effective in treating certain reproductive disorders, notably pyometra (uterine infection), by inducing uterine contractions to expel pus and causing luteolysis if a corpus luteum is present, thereby resolving the condition. It is also used to induce parturition (calving, foaling, farrowing) in some cases to manage birth timing or for medical reasons, and to terminate undesirable pregnancies.

The production of high-quality Dinoprost API (CAS 551-11-1) requires stringent manufacturing processes to ensure purity, stability, and efficacy. As a complex molecule, the synthesis and handling of Dinoprost powder demand adherence to international standards such as GMP (Good Manufacturing Practice) and ISO 9001, as mentioned in industry specifications. Proper storage conditions – sealed in a cool, dry place – are crucial for maintaining the integrity and potency of the API before it is formulated into finished drug products. The white powder form simplifies handling and incorporation into various pharmaceutical preparations, most commonly sterile injectable solutions for both human and veterinary use.

The global demand for reproductive health pharmaceuticals, particularly in the burgeoning veterinary market driven by livestock production needs, underscores the continued importance of Dinoprost API. As a reliable manufacturer and supplier of pharmaceutical raw materials, NINGBO INNO PHARMCHEM CO.,LTD. recognizes the critical need for consistent quality and supply chain reliability for APIs like Dinoprost (CAS 551-11-1). Companies seeking to buy or purchase high-purity Dinoprost powder require transparent information regarding product specifications, testing methods, and compliance with regulatory requirements. Factors influencing the price of this API include purity levels, manufacturing volume, packaging, and transport logistics. Ensuring a secure and efficient supply chain is paramount for pharmaceutical companies developing and distributing Dinoprost-based medications worldwide. Inquiries about the technical details, availability, and how to purchase high-quality Dinoprost API are welcomed by reputable manufacturers and suppliers dedicated to serving the pharmaceutical industry.