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Vitamin B6, primarily in its active form Pyridoxal 5'-Phosphate (P5P), is essential for numerous physiological processes. While a deficiency in Vitamin B6 is not as common as other B vitamins, it can occur, particularly in individuals with certain medical conditions or dietary restrictions. Recognizing the symptoms of P5P deficiency is crucial for timely intervention and maintaining overall health.
Symptoms associated with Vitamin B6 deficiency can be varied and often overlap with deficiencies of other B vitamins. However, characteristic signs may include a seborrheic dermatitis-like skin rash, inflammation of the tongue (atrophic glossitis), cracks at the corners of the mouth (angular cheilitis), and neurological symptoms such as confusion, irritability, depression, and peripheral neuropathy. The neuropathy is thought to be related to impaired synthesis of sphingolipids, essential components of nerve cell membranes. Anemia, specifically sideroblastic anemia, can also occur due to P5P's role in heme synthesis.
Causes of Vitamin B6 deficiency can stem from inadequate dietary intake, though this is rare. More commonly, deficiency arises from conditions that impair its absorption or metabolism. These include alcoholism, celiac disease, Crohn's disease, and kidney disorders. Certain medications, such as isoniazid (used to treat tuberculosis) and some anticonvulsants, can also interfere with Vitamin B6 metabolism. Elderly individuals and those with chronic inflammatory conditions are also at an increased risk.
The diagnosis of Vitamin B6 deficiency is typically made through biochemical tests, such as measuring plasma PLP levels or assessing the activation coefficient of erythrocyte aspartate aminotransferase. Since P5P is the metabolically active form, ensuring adequate levels through diet or supplementation is important. While foods like meat, fish, fortified cereals, and bananas are good sources of Vitamin B6, the bioavailability of P5P as a supplement ensures direct access to the active form for therapeutic or preventative purposes. Understanding pyridoxal 5 phosphate deficiency symptoms underscores the importance of maintaining optimal P5P levels for a healthy nervous system and skin.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
