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Helicobacter pylori (H. pylori) infection is a global health challenge, strongly linked to peptic ulcers, gastritis, and gastric cancers. The standard treatment involves a combination of antibiotics and a gastric acid suppressor, typically a proton pump inhibitor (PPI). However, the rising rates of antibiotic resistance and limitations in PPI efficacy have necessitated the development of more effective strategies. NINGBO INNO PHARMCHEM CO.,LTD. highlights the pivotal role Vonoprazan Fumarate is playing in this evolving landscape.
The efficacy of H. pylori eradication regimens is critically dependent on adequate gastric acid suppression. This suppression is vital for creating an environment conducive to antibiotic activity and for preventing the bacteria from entering a less susceptible dormant state. While PPIs have been instrumental, their effectiveness can be hampered by factors such as genetic CYP2C19 polymorphisms, which affect drug metabolism, and their less potent effect during nighttime hours. This is where Vonoprazan Fumarate, a potassium-competitive acid blocker (P-CAB), offers a distinct advantage.
Vonoprazan Fumarate's mechanism of action ensures a more potent and sustained inhibition of gastric acid secretion, irrespective of CYP2C19 genotype and unaffected by meal timing. This consistent acid suppression creates a more favorable environment for antibiotics, leading to improved eradication rates. Numerous studies have demonstrated the superiority of vonoprazan-based therapies in eradicating H. pylori, particularly when compared to PPI-based regimens. This advantage is especially pronounced in regions with high rates of clarithromycin resistance, a common challenge in H. pylori treatment.
The enhanced pharmacodynamic properties of Vonoprazan Fumarate allow it to synergize more effectively with antibiotics, potentially leading to higher cure rates and fewer treatment failures. The ability to achieve rapid and prolonged acid suppression from the first dose is a significant benefit, contributing to better patient compliance and overall treatment success. As NINGBO INNO PHARMCHEM CO.,LTD. continues to support advancements in pharmaceutical science, Vonoprazan Fumarate stands out as a key innovation in addressing the complexities of H. pylori eradication and improving patient health outcomes.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
