At NINGBO INNO PHARMCHEM CO.,LTD., we delve into the molecular intricacies of the chemicals we supply. Aztreonam (CAS 78110-38-0) is a fascinating synthetic compound whose chemical structure dictates its unique biological activity and research utility. Understanding its chemistry is key to appreciating its role in combating Gram-negative bacterial infections.

Aztreonam is classified as a monobactam, meaning it contains a single beta-lactam ring, unlike penicillins and cephalosporins which have fused ring systems. This structural difference is significant. The beta-lactam ring is the pharmacologically active component that interacts with bacterial enzymes. In Aztreonam, the arrangement of atoms around this ring, particularly the sulfamic acid group, contributes to its stability against many beta-lactamase enzymes. This chemical stability is a major reason why Aztreonam is employed in research to study bacterial resistance mechanisms and to test the effectiveness of antibiotics in challenging environments.

Chemically, Aztreonam is a white to off-white crystalline powder. Its solubility properties are important for its preparation in laboratory settings and for potential therapeutic formulations. While it exhibits solubility in certain organic solvents like DMSO and DMF, its solubility in water is limited, which influences how it is handled and administered in research protocols. The precise molecular weight and formula (C13H17N5O8S2) are critical for stoichiometric calculations in experiments.

Researchers often purchase Aztreonam from suppliers like NINGBO INNO PHARMCHEM CO.,LTD. to investigate its interactions with bacterial targets. The price of Aztreonam reflects the complexity of its synthesis and purification, ensuring a high-quality product for scientific investigation. The stability and specific binding characteristics of Aztreonam to Penicillin-Binding Protein 3 (PBP3) are direct consequences of its chemical structure, making it a valuable tool for understanding bacterial cell wall synthesis.

In essence, the chemistry of Aztreonam provides the foundation for its role as a potent antibacterial agent and a crucial research chemical. Its unique structure and resulting properties continue to be explored for their implications in developing future anti-infective strategies.