At NINGBO INNO PHARMCHEM CO.,LTD., we recognize the profound impact of NAD+ on cellular integrity. Beyond its well-known role in energy metabolism, NAD+ is a crucial player in DNA repair, bolstering cellular resilience against damage. This article explores how NAD+ supports these vital processes and contributes to overall cellular health.

Central to DNA integrity are enzymes like Poly(ADP-ribose) polymerase (PARP) and sirtuins. These enzymes utilize NAD+ as a substrate to carry out essential functions. PARP enzymes, for instance, are rapidly activated upon DNA damage. They use NAD+ to synthesize poly(ADP-ribose) chains onto target proteins, signaling and recruiting other repair factors to the site of damage. This intricate process, facilitated by NAD+, is paramount for repairing breaks in the DNA strand and preventing genomic instability.

Sirtuins, another class of NAD+-dependent enzymes, are often referred to as 'longevity genes.' They function as deacetylases, removing acetyl groups from proteins, including histones that package DNA. By deacetylating histones, sirtuins can influence gene expression and chromatin structure, thereby playing a role in cellular stress responses and DNA repair pathways. The activity of sirtuins is directly tied to NAD+ levels; as NAD+ levels decline, sirtuin activity can be compromised, potentially impacting the cell's ability to repair itself and maintain resilience.

The availability of NAD+ is therefore critical for maintaining robust DNA repair mechanisms. As we age, NAD+ levels naturally decrease, which can impair the efficiency of these repair processes. This decline can lead to an accumulation of DNA damage, contributing to cellular senescence and the onset of age-related diseases. Understanding the NAD+ functions in cells is key to developing strategies that support these repair processes.

The importance of NAD+ in cellular resilience makes it a significant target for interventions aimed at promoting healthy aging. Research into NAD+ precursor supplementation, such as with nicotinamide mononucleotide (NMN), aims to boost NAD+ levels and, by extension, enhance the cell's intrinsic repair capabilities. At NINGBO INNO PHARMCHEM CO.,LTD., we are dedicated to providing high-quality ingredients that support these cellular processes, contributing to greater cellular resilience and overall well-being.