NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing comprehensive information on the chemicals we supply, including critical building blocks like Fmoc-Orn(Z)-OH (CAS 138775-07-2). This article explores the fundamental chemical properties and synthesis pathways of Fmoc-Orn(Z)-OH, offering valuable insights for researchers and chemists working with this important compound.

Fmoc-Orn(Z)-OH, chemically known as N-alpha-(9-Fluorenylmethoxycarbonyl)-N-delta-benzyloxycarbonyl-L-ornithine, possesses a molecular formula of C28H28N2O6 and a molecular weight of approximately 488.53 g/mol. Its appearance is typically described as a white to off-white solid, indicating its stable nature at room temperature, which is advantageous for storage and handling in laboratory settings. The melting point information, if available, would further confirm its solid state and purity.

The synthesis of Fmoc-Orn(Z)-OH involves a multi-step process. Typically, L-ornithine is first protected on its side chain with the benzyloxycarbonyl (Z) group. Subsequently, the alpha-amino group is protected with the 9-fluorenylmethoxycarbonyl (Fmoc) group. Each step requires carefully controlled reaction conditions, including appropriate solvents, reagents, and temperatures, to ensure high yields and minimal side products. For example, the Fmoc protection is often achieved using Fmoc-OSu (N-hydroxysuccinimide ester of Fmoc) or Fmoc-Cl (Fmoc chloride) in the presence of a base.

The efficiency and purity of the Fmoc-Orn(Z)-OH synthesis are critical. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. employ advanced purification techniques, such as recrystallization and chromatography, to isolate Fmoc-Orn(Z)-OH in high purity (often >98% by HPLC). This high purity is essential for its successful application in peptide synthesis, where contaminants can lead to incorrect sequences or reduced coupling efficiencies. Researchers often look for details on the synthesis process when evaluating Fmoc-Orn(Z)-OH suppliers.

The chemical properties of Fmoc-Orn(Z)-OH are directly related to its functional groups. The Fmoc group is labile to mild bases (like piperidine), facilitating its removal during peptide elongation. The Z group on the side chain is typically removed by catalytic hydrogenation or strong acids, providing an orthogonal deprotection strategy. Understanding these properties is key to effectively utilizing Fmoc-Orn(Z)-OH in various Fmoc-Orn(Z)-OH applications, including the synthesis of complex peptide structures and its use as an intermediate in antifungal evaluations.

When considering the Fmoc-Orn(Z)-OH price, it reflects the complexity of its synthesis, the cost of raw materials, and the stringent quality control measures in place. NINGBO INNO PHARMCHEM CO.,LTD. strives to offer competitive pricing while maintaining the highest product quality, ensuring that researchers have access to reliable peptide synthesis reagents.

In summary, the chemical properties and synthesis of Fmoc-Orn(Z)-OH are central to its utility in peptide chemistry and beyond. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing researchers with high-quality Fmoc-Orn(Z)-OH, backed by a deep understanding of its chemistry and production processes.