Posted by NINGBO INNO PHARMCHEM CO.,LTD.

Tetramethylpyrazine, identified by its CAS number 1124-11-4, is a compound whose chemical profile is of immense interest to industries globally. Its unique molecular structure and resulting properties make it a valuable asset, particularly in the food and pharmaceutical sectors. This article will dissect the synthesis, chemical properties, and industrial relevance of Tetramethylpyrazine, underscoring why understanding its chemical properties is paramount for its effective utilization.

The synthesis of Tetramethylpyrazine typically involves the condensation of 2,3-butanedione with 2,3-butanediamine. Other methods include the reduction and cyclization of butanedione monoxime, derived from the condensation of butanone and ethyl nitrite. These processes are engineered to yield a high-purity product, often exceeding 98%, which is critical for its applications. The compound itself is an alkaloid, falling under the pyrazine class of organic compounds. Its molecular formula is C8H12N2, and it has a molecular weight of approximately 136.19 g/mol. The stability of Tetramethylpyrazine is generally good, though it should be stored away from strong acids and oxidizing agents.

Physically, Tetramethylpyrazine typically appears as white crystals or a fine powder. It possesses a characteristic aroma described as nutty, cocoa-like, or even reminiscent of roasted meat and coffee. Its melting point is in the range of 77-80°C, and its boiling point is around 190°C. Its solubility in water is limited (4 g/L at 20°C), but it readily dissolves in ethanol and other organic solvents. These physical attributes are vital for formulators in both the food industry, where it's used as a flavoring agent, and the pharmaceutical industry, where it serves as a pharmaceutical intermediate.

The industrial relevance of Tetramethylpyrazine is multifaceted. In the food industry, its role in creating nuanced flavors for chocolates, coffees, and savory products is well-established. Its ability to mimic natural aromas makes it a cost-effective and consistent ingredient for flavor houses. In pharmaceuticals, the compound, often referred to as 2,3,5,6-tetramethylpyrazine, is investigated and utilized for its pharmacological effects, including the improvement of microcirculation and its potential in treating vascular and neurological conditions. Sourcing this compound from reliable suppliers in China is a common practice for companies worldwide, ensuring access to quality material.

In conclusion, the detailed chemical profile of Tetramethylpyrazine (CAS 1124-11-4) reveals a compound with significant industrial utility. Its straightforward synthesis, combined with desirable sensory and pharmacological properties, solidifies its position as a key ingredient in numerous applications. For professionals in chemistry, food science, and pharmaceuticals, a thorough understanding of Tetramethylpyrazine's synthesis and properties is essential for unlocking its full potential.