4-Amino-3-iodobenzotrifluoride (CAS 163444-17-5) is a sophisticated chemical compound that plays a pivotal role in modern organic chemistry. Its unique combination of functional groups—an amino group, an iodine atom, and a trifluoromethyl group on a benzene ring—renders it exceptionally versatile for various synthetic applications. NINGBO INNO PHARMCHEM CO.,LTD. is a trusted provider of this essential chemical intermediate, offering valuable insights into its chemistry.

Understanding the Chemical Structure and Properties

The molecular structure of 4-Amino-3-iodobenzotrifluoride is central to its utility. The amino (-NH2) group provides nucleophilic characteristics, while the iodine atom is an excellent leaving group in metal-catalyzed cross-coupling reactions. The trifluoromethyl (-CF3) group is a powerful electron-withdrawing moiety, influencing the reactivity of the aromatic ring and enhancing properties such as lipophilicity and metabolic stability, which are highly desirable in pharmaceutical and agrochemical development.

Physically, this compound typically presents as a white to off-white crystalline powder. Its molecular weight is approximately 287.02 g/mol, and it has a stated purity of ≥98.0%. Key physical parameters, such as a melting point of around 50°C, indicate its solid state under ambient conditions. Its chemical reactivity makes it a prime candidate for various synthetic transformations, including nucleophilic substitutions and electrophilic aromatic substitutions.

Synthesis Pathways and Production Excellence

The synthesis of 4-Amino-3-iodobenzotrifluoride often involves multi-step processes that require precise control over reaction conditions. Common synthetic routes leverage the reactivity of aniline derivatives, involving steps like iodination and the introduction or modification of functional groups. Achieving high purity and yield is critical, a challenge that manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. address through optimized processes and rigorous quality control.

The efficiency of organic synthesis using this intermediate is directly linked to its purity. Suppliers ensure that the product is free from significant impurities that could interfere with subsequent reactions, thereby maintaining the integrity of the final product. The ability to buy 4-Amino-3-iodobenzotrifluoride from a reliable source like NINGBO INNO PHARMCHEM CO.,LTD. streamlines research and development efforts.

Safety, Storage, and Handling Recommendations

Proper handling and storage are crucial for maintaining the quality and safety of 4-Amino-3-iodobenzotrifluoride. It is generally recommended to store the compound in a cool, dry, and well-ventilated place, away from direct sunlight and sources of ignition. Given its chemical nature, appropriate personal protective equipment (PPE), such as gloves, safety glasses, and lab coats, should be worn when handling it. Understanding its potential hazards, including irritation upon contact or inhalation, is vital for safe laboratory practices.

When sourcing from NINGBO INNO PHARMCHEM CO.,LTD., customers can rely on detailed product specifications and safety data sheets (SDS) that provide comprehensive guidance on handling, storage, and emergency procedures. This ensures that users can confidently integrate this compound into their workflows, whether for small-scale research or large-scale manufacturing.

The continued development in pharmaceuticals, agrochemicals, and materials science relies heavily on access to high-quality chemical intermediates. 4-Amino-3-iodobenzotrifluoride, with its versatile chemical profile, is set to remain a key player in these advancements, supported by dependable suppliers like NINGBO INNO PHARMCHEM CO.,LTD.