Diethyl Acetylenedicarboxylate (CAS 762-21-0), often abbreviated as DEAD or DEADC, is a powerful and versatile chemical reagent widely employed in organic synthesis. Its symmetrical structure and the presence of electron-withdrawing ester groups make the alkyne moiety highly reactive towards nucleophilic attack and cycloaddition reactions. This characteristic makes it a cornerstone for chemists aiming to construct complex organic molecules efficiently.

One of the most prominent reaction pathways involving Diethyl Acetylenedicarboxylate is the Diels-Alder reaction. Acting as a dienophile, it readily reacts with conjugated dienes to form six-membered rings. This [4+2] cycloaddition is fundamental in the synthesis of numerous cyclic compounds, including pharmaceuticals and natural products. Understanding the regioselectivity and stereoselectivity of these reactions is key to harnessing the full potential of Diethyl Acetylenedicarboxylate in synthesizing target molecules. For those looking to buy Diethyl Acetylenedicarboxylate, its predictable behavior in Diels-Alder reactions is a major draw.

Another critical reaction is the Michael addition, where Diethyl Acetylenedicarboxylate acts as a potent Michael acceptor. Nucleophiles, such as amines, thiols, and stabilized carbanions, can add to the electron-deficient triple bond, leading to the formation of functionalized alkenes. These adducts are valuable intermediates for further synthetic transformations. The ability to buy Diethyl Acetylenedicarboxylate at a reasonable price from suppliers like NINGBO INNO PHARMCHEM CO.,LTD. ensures that these synthetic routes remain economically viable.

Beyond these fundamental reactions, Diethyl Acetylenedicarboxylate is also utilized in multicomponent reactions and cascade processes, enabling the rapid assembly of molecular complexity in a single pot. Its application in synthesizing heterocycles, which are prevalent in medicinal chemistry, further highlights its importance. The price of Diethyl Acetylenedicarboxylate is a testament to its broad utility and the sophisticated chemistry it facilitates, making it an indispensable tool for organic chemists globally.

NINGBO INNO PHARMCHEM CO.,LTD. provides high-quality Diethyl Acetylenedicarboxylate, ensuring purity and consistency for all your synthetic needs. Our commitment to excellence means you can rely on us for your research and production requirements.