The fundamental principle of maintaining a stable pH is critical across a vast spectrum of biological processes. At NINGBO INNO PHARMCHEM CO.,LTD., we are dedicated to providing the scientific community with reagents that uphold this essential requirement. Bicine, a prominent zwitterionic organic compound (CAS No: 150-25-4), exemplifies this by serving as a highly effective biological buffer. Its inherent chemical structure and properties make it an invaluable asset in laboratories undertaking diverse biochemical research.

The effectiveness of any buffer is largely determined by its pKa value, which indicates the pH at which the acidic and conjugate base forms of the molecule are present in equal concentrations. Bicine possesses a pKa of 8.35 at 20°C. This specific pKa means that Bicine is most effective at buffering in the slightly alkaline range, typically between pH 7.6 and 9.0. This pH range is frequently encountered in many biological systems, particularly those involving enzymes that function optimally in these conditions. Researchers looking to buy Bicine are often drawn to its reliability within this critical pH window.

The stability Bicine offers is crucial for numerous biochemical reactions. Enzymes, the catalysts of life, are highly sensitive to pH fluctuations, and deviations from their optimal range can lead to reduced activity or even denaturation. By incorporating Bicine into reaction mixtures, scientists can ensure that the pH remains constant, thereby promoting consistent enzyme kinetics and yielding reproducible experimental results. This is especially relevant when preparing stable substrate solutions, a common requirement in many analytical assays.

The scientific literature also highlights Bicine's role in other advanced applications. Its use in low-temperature biochemical research underscores its broad applicability. Furthermore, Bicine has been observed to enhance protein stability, a feature that is highly advantageous for processes like protein crystallization and various forms of chromatography, including ion exchange chromatography. These applications demand buffers that not only control pH but also do not interfere with the delicate structural integrity of proteins. The price for such high-quality Bicine from suppliers like NINGBO INNO PHARMCHEM CO.,LTD. reflects its importance in scientific research.

Beyond its direct buffering role, Bicine has also been noted in certain contexts as an amine degradation product in industrial settings. However, within the controlled environment of a laboratory, its intended use as a high-purity buffer reagent is paramount. Sourcing Bicine with a purity of ≥99.0% from a trusted supplier like NINGBO INNO PHARMCHEM CO.,LTD. ensures that the scientific integrity of your research is maintained.

In conclusion, Bicine is a vital biological buffer whose scientific underpinnings—specifically its pKa and resulting pH stability—make it indispensable for modern biochemical research. Its applications extend to critical areas like enzyme function, substrate solution preparation, protein stability, and chromatography. For researchers requiring a dependable source of high-quality Bicine, NINGBO INNO PHARMCHEM CO.,LTD. stands ready to support your scientific endeavors.