The pharmaceutical sector's reliance on high-quality chemical intermediates is fundamental to the development and manufacturing of safe and effective medicines. 4-(4-Chlorophenyl)piperidin-4-ol, identified by its CAS number 39512-49-7, is a critical intermediate, primarily used in the synthesis of Loperamide hydrochloride. Understanding its synthesis, stringent specifications, and the importance of supply chain reliability is essential for any organization involved in its procurement and use.

The synthesis of 4-(4-Chlorophenyl)piperidin-4-ol involves precise organic chemistry reactions to yield a product that meets specific quality criteria. Its typical form as a white to yellow crystalline powder is a visual indicator of its processed nature, but the true measure of its quality lies in its specifications. A high assay, often exceeding 98.0%, is crucial for its intended pharmaceutical applications. This high purity ensures that the subsequent steps in the synthesis of Loperamide hydrochloride are efficient and that the final API is free from detrimental impurities. Factors such as density (around 1.2 g/cm³), melting point (137-140°C), and flash point (162.1°C) are also important parameters that guide its safe handling and integration into manufacturing processes.

The reliability of the supply chain for pharmaceutical intermediates like 4-(4-Chlorophenyl)piperidin-4-ol is paramount. Disruptions or inconsistencies in supply can have significant ripple effects on drug production schedules and market availability. Pharmaceutical companies therefore prioritize sourcing from manufacturers and suppliers who demonstrate a robust commitment to quality control, timely delivery, and transparent communication. Manufacturers in China, such as NINGBO INNO PHARMCHEM CO.,LTD., often possess the infrastructure and expertise to meet these demands, offering not only standard products but also custom synthesis and contract manufacturing services tailored to specific client needs.

The effective utilization of 4-(4-Chlorophenyl)piperidin-4-ol as a key intermediate underscores the critical interplay between chemical manufacturing and pharmaceutical development. By focusing on delivering precisely specified, high-purity materials through a reliable supply chain, manufacturers contribute directly to the availability of essential medications like Loperamide hydrochloride, ultimately benefiting global health outcomes.