In the specialized field of peptide synthesis, the quest for high-purity products is relentless. NINGBO INNO PHARMCHEM CO.,LTD. is at the forefront of supplying critical chemical intermediates that facilitate this goal, with Boc-Asn(Trt)-OH being a prime example. Known chemically as N-alpha-Boc-N-gamma-trityl-L-asparagine and identified by CAS 132388-68-2, this compound is indispensable for researchers who prioritize purity and efficiency in their peptide synthesis endeavors.

The challenge in incorporating asparagine residues into peptide chains lies in the inherent instability of the side chain. Aspartimide formation, a cyclization reaction of the side-chain amide, is a common complication that can lead to a mixture of products, making purification difficult and reducing the yield of the desired peptide. The incorporation of the trityl (Trt) protecting group on the gamma-amide of asparagine, as seen in Boc-Asn(Trt)-OH, serves as a crucial protective measure. This bulky group effectively shields the amide nitrogen, preventing the formation of unwanted cyclic by-products during the Solid-Phase Peptide Synthesis (SPPS) process.

Beyond its protective function, the trityl group significantly enhances the solubility of asparagine derivatives in the polar organic solvents typical for SPPS. This improved solubility translates directly into more efficient coupling steps, reducing the reaction times and the amount of reagents needed, ultimately lowering the overall buy/purchase cost for laboratories. The ability to reliably incorporate asparagine without compromising the purity of the growing peptide chain makes Boc-Asn(Trt)-OH a highly sought-after component.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to supplying researchers with the finest quality reagents. Our Boc-Asn(Trt)-OH is manufactured to stringent purity standards, ensuring that it meets the demands of even the most sensitive peptide synthesis applications. By providing this essential building block, we support advancements in areas ranging from pharmaceutical development to biochemical research, making high-purity peptide synthesis more accessible and achievable for our clients.