Understanding the intricate chemical and physical properties of pharmaceutical intermediates is crucial for their successful application in drug synthesis. 4-(4-Chlorophenyl)piperidin-4-ol, with the CAS number 39512-49-7, is a notable example, serving as a key intermediate, most famously in the production of Loperamide hydrochloride. This compound's well-defined characteristics make it a valuable asset in medicinal chemistry and pharmaceutical manufacturing.

Chemically, 4-(4-Chlorophenyl)piperidin-4-ol is identified by its molecular formula C11H14ClNO and a molecular weight of 211.69 g/mol. Its structure features a piperidine ring substituted with a p-chlorophenyl group and a hydroxyl group, conferring specific reactivity and physical properties. The compound typically presents as a white to yellow crystalline powder, a characteristic that often indicates a good degree of purity. Physical data, such as its density of approximately 1.2±0.1 g/cm³ and a melting point in the range of 137-140°C, provide essential information for handling, storage, and process design. Furthermore, its flash point of 162.1±27.9°C suggests a moderate level of flammability, requiring standard safety precautions during industrial use.

The primary application of 4-(4-Chlorophenyl)piperidin-4-ol lies in its role as an intermediate for Loperamide hydrochloride (CAS 34552-83-5). Loperamide is an opioid-receptor agonist that reduces the activity of the myenteric plexus in the large intestine, thereby decreasing intestinal motility and fluid secretion. The precise structure of 4-(4-Chlorophenyl)piperidin-4-ol contributes the necessary phenyl and hydroxyl functionalities that are critical for building the Loperamide molecule. This makes it an indispensable component in the multi-step synthesis of this widely used medication.

For pharmaceutical manufacturers, sourcing this intermediate from reliable providers who can guarantee an assay of ≥98.0% is vital. Companies like NINGBO INNO PHARMCHEM CO.,LTD., as reputable manufacturers and suppliers, ensure that the compound is produced under strict quality control measures. This commitment to quality not only facilitates seamless integration into the synthesis process but also contributes to the overall safety and efficacy of the final drug product. The consistent availability of such well-characterized intermediates is fundamental to the efficient operation of the global pharmaceutical industry.