In the pharmaceutical industry, the purity of every component, especially critical intermediates, directly impacts the quality and safety of the final drug product. 4-(4-Chlorophenyl)piperidin-4-ol (CAS 39512-49-7) is a prime example of such an intermediate, playing a pivotal role in the synthesis of Loperamide hydrochloride, a widely prescribed antidiarrheal medication. Ensuring the highest possible purity for this compound is a hallmark of responsible pharmaceutical manufacturing.

The chemical structure of 4-(4-Chlorophenyl)piperidin-4-ol, characterized by its specific arrangement of chlorine, phenyl, and piperidine groups, is engineered to facilitate the subsequent steps in the Loperamide synthesis. Its typical presentation as a white to yellow crystalline powder suggests a refined product. However, the true measure of its value lies in its assay, which often needs to meet stringent requirements, typically ≥98.0%. This high purity is critical because any impurities present in the intermediate could carry through the synthesis process, potentially leading to the formation of undesired by-products or affecting the stability and therapeutic activity of the Loperamide hydrochloride.

Pharmaceutical companies rely on manufacturers who can consistently deliver intermediates of this caliber. Sourcing 4-(4-Chlorophenyl)piperidin-4-ol from trusted suppliers in China, such as NINGBO INNO PHARMCHEM CO.,LTD., is essential. These suppliers are expected to adhere to rigorous quality assurance protocols, including advanced analytical testing to verify purity and identify any trace impurities. The ability to provide comprehensive documentation, such as Certificates of Analysis (CoA), further reinforces confidence in the material's quality.

The consistent availability of high-purity 4-(4-Chlorophenyl)piperidin-4-ol ensures that the production of Loperamide hydrochloride can proceed smoothly, meeting market demands without compromising on quality. This focus on purity underscores the commitment of both the intermediate manufacturer and the final drug producer to patient safety and therapeutic efficacy. Ultimately, the diligent management of intermediate quality, exemplified by 4-(4-Chlorophenyl)piperidin-4-ol, is a cornerstone of successful pharmaceutical manufacturing.