2-Mercapto-N-Methylbenzamide, with the CAS number 20054-45-9, is a molecular entity that holds significant value within the pharmaceutical and chemical research sectors. Its primary recognition comes from its indispensable role as an intermediate in the synthesis of Axitinib, a targeted therapy for certain types of cancer. This article explores its key chemical properties and diverse applications, highlighting its importance in advanced chemical synthesis.

Chemically, 2-Mercapto-N-Methylbenzamide (C8H9NOS, Molecular Weight: 167.23 g/mol) presents as an off-white to pale beige crystalline powder. Its melting point typically falls within the range of 94-96 °C, indicating it exists as a solid at standard room temperature. The compound is described as air-sensitive, necessitating proper storage conditions, ideally under an inert atmosphere and refrigeration (2-8°C), to maintain its integrity and purity. Its solubility in solvents like acetonitrile, chloroform, and methanol is noted as slight, which is a common characteristic for many organic intermediates.

The synthesis of 2-Mercapto-N-Methylbenzamide itself can be achieved through various routes. One described method involves reacting 2-hydroxy-N-methylbenzamide with reagents such as dimethylaminothioformyl chloride in the presence of a catalyst or base like triethylene diamine or N,N-diisopropylethylamine. These synthetic pathways are crucial for ensuring high yields and purity, which are critical for its subsequent use in pharmaceutical intermediate synthesis.

The principal application of 2-Mercapto-N-Methylbenzamide is as a precursor for Axitinib (A794650). Axitinib functions as a potent tyrosine kinase inhibitor, targeting specific pathways involved in cancer cell growth and angiogenesis. Consequently, 2-Mercapto-N-Methylbenzamide is a vital component for companies involved in the research and development of novel cancer treatments and other tyrosine kinase inhibitor intermediates.

Beyond Axitinib, the chemical structure of 2-Mercapto-N-Methylbenzamide, featuring a mercapto group and an amide linkage, suggests potential utility as a building block in other areas of organic synthesis. Researchers exploring new molecular entities might find this compound useful for introducing specific functional groups into larger molecular frameworks. The ease with which one can buy 2-mercapto-N-methylbenzamide online makes it an accessible tool for various chemical endeavors.

In essence, 2-Mercapto-N-Methylbenzamide exemplifies the critical role that intermediate chemicals play in advancing scientific and medical frontiers. Its defined chemical properties and established application in the synthesis of a life-saving drug underscore its importance in the global pharmaceutical supply chain. Ningbo Inno Pharmchem Co., Ltd. is dedicated to providing such high-quality intermediates to fuel innovation.