At NINGBO INNO PHARMCHEM CO.,LTD., we are committed to providing researchers with thorough scientific data on compounds crucial for advancing pharmaceutical research. Today, we focus on ABT-737 (CAS 852808-04-9), a significant BH3 mimetic, delving into its chemical properties and biological activity, which are key to understanding its therapeutic potential.

ABT-737, with the molecular formula C42H45ClN6O5S2 and a molecular weight of 813.43, is characterized by a complex structure that enables its potent interaction with the Bcl-2 protein family. Chemically, it presents as a white powder, which is standard for many research-grade organic compounds. Understanding its solubility is critical for experimental design. ABT-737 is readily soluble in DMSO (greater than 40.67 mg/mL), a common solvent for many small molecules in biological research. However, it is notably insoluble in ethanol and water, which dictates how it must be prepared for various assays and applications.

The biological activity of ABT-737 is primarily defined by its role as a potent inhibitor of anti-apoptotic proteins. Its EC50 values demonstrate high binding affinity to Bcl-2 (30.3 nM), Bcl-xL (78.7 nM), and Bcl-w (197.8 nM) in cell-free assays. Crucially, it shows minimal to no inhibition against other related proteins like Mcl-1, Bcl-B, or Bfl-1, indicating a degree of selectivity. This selective inhibition is fundamental to its mechanism of inducing apoptosis through the Bax-Bak pathway, which is a central theme in ABT-737 mechanism of action research.

The extensive research on ABT-737 has elucidated its efficacy across various cancer cell lines, including those derived from small-cell lung cancer, lymphoma, and multiple myeloma. Its ability to induce apoptosis, even in cells resistant to other treatments, highlights its significance in ABT-737 cancer therapy development. The detailed studies on its biological activity, including concentration-dependent effects on cell viability and apoptosis induction, provide invaluable data for researchers.

The chemical name for ABT-737 is 4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamide. This complex structure contributes to its ability to engage with its protein targets effectively. Researchers often utilize compounds like ABT-737 in various experimental setups, from in vitro cell-based assays to in vivo preclinical models, to study the intricacies of apoptosis and explore new therapeutic strategies. The consistent availability of high-purity ABT-737 from reliable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. is essential for reproducible results.

Beyond its oncological applications, the exploration of ABT-737 research applications in areas such as neuroscience and aging is expanding, showcasing the multifaceted nature of this molecule. The detailed understanding of its Bcl-2 family protein inhibition capabilities provides a foundation for these broader investigations.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to facilitating scientific discovery by providing high-quality chemical compounds and comprehensive data. Our aim is to support researchers in their exploration of molecules like ABT-737, driving progress in drug development and therapeutic innovation.