At NINGBO INNO PHARMCHEM CO.,LTD., we are dedicated to understanding the intricate science behind pharmaceutical tablet formulation. A critical aspect of this is ensuring that tablets disintegrate rapidly and efficiently, allowing for the timely release and absorption of the active pharmaceutical ingredient (API). Sodium Starch Glycolate (SSG) is one of the most effective superdisintegrants available, and our team expertly utilizes its unique properties to achieve optimal tablet performance. This article explores the scientific basis for SSG's efficacy and its importance in our product development.

The primary function of a superdisintegrant like Sodium Starch Glycolate (CAS No. 9063-38-1) is to accelerate the disintegration process of a tablet. Unlike traditional disintegrants, superdisintegrants exhibit superior performance due to their enhanced water-uptake and swelling capacities. SSG, being a modified starch, is designed to imbibe a large volume of water rapidly. This rapid hydration causes the SSG particles within the tablet matrix to swell considerably. As these particles expand, they generate a significant mechanical force that pushes the tablet apart, effectively breaking it into smaller, more manageable pieces. This mechanism is particularly effective in cold water, highlighting SSG's potent disintegration capabilities.

Furthermore, SSG offers the advantage of improving tablet hardness without negatively impacting its disintegration time. This means that tablets formulated with SSG can be manufactured to possess good physical strength, which is crucial for their stability during production, packaging, and transit. Yet, upon contact with moisture, they readily break down. This dual capability is invaluable in achieving a balance between tablet robustness and rapid drug release. The optimal concentration for SSG typically falls between 2% and 10%, a range where NINGBO INNO PHARMCHEM CO.,LTD. carefully calibrates its use to maximize benefits.

The inherent properties of Sodium Starch Glycolate also make it highly compatible with various APIs and suitable for different manufacturing techniques, including direct compression and wet granulation. At NINGBO INNO PHARMCHEM CO.,LTD., we harness the power of SSG to not only ensure rapid drug release but also to potentially improve the bioavailability of challenging, poorly soluble drugs. Our commitment to using high-quality SSG ensures that our pharmaceutical products deliver the intended therapeutic effects efficiently and reliably, underscoring our expertise in advanced tablet formulation.