The production of high-quality pharmaceutical intermediates is a blend of art and science, and 1-(4-Iodophenyl)-2-Piperidinone (CAS: 385425-15-0) exemplifies this perfectly. At NINGBO INNO PHARMCHEM CO.,LTD., we are dedicated to mastering the chemical synthesis of this crucial compound, which serves as a vital intermediate for the antithrombotic drug Apixaban.

The synthesis of 1-(4-Iodophenyl)-2-Piperidinone primarily involves a two-step process: amidation followed by cyclization. The key raw materials are 4-Iodoaniline and 5-Bromovaleryl Chloride. The amidation step couples the amine group of 4-Iodoaniline with the acid chloride group of 5-Bromovaleryl Chloride, forming an amide. This is followed by an intramolecular cyclization reaction, where the amine nitrogen attacks the terminal carbon atom of the alkyl chain, closing the ring structure to form the piperidinone moiety. The precise control of reaction conditions, such as temperature, solvent, and catalyst, is paramount to achieving the desired product with high purity and yield.

Achieving the stringent purity requirements for pharmaceutical intermediates like 1-(4-Iodophenyl)-2-Piperidinone (≥98.5% by HPLC) necessitates rigorous quality control at every stage of the synthesis. This includes careful selection of raw materials, monitoring reaction progress, and employing advanced purification techniques. Impurities, even in small amounts, can significantly affect the efficacy and safety of the final drug. Therefore, NINGBO INNO PHARMCHEM CO.,LTD., as a leading pharmaceutical intermediate manufacturer in China, invests heavily in analytical testing and process optimization to ensure consistent quality.

The demand for Apixaban, a key player in the antithrombotic market, directly fuels the need for reliable suppliers of its intermediates. Companies seeking to buy 1-(4-Iodophenyl)-2-Piperidinone can trust NINGBO INNO PHARMCHEM CO.,LTD. for its commitment to quality and expertise in chemical synthesis. Our role as a premier 1-(4-Iodophenyl)-2-Piperidinone supplier in China ensures that the complex journey from raw materials to life-saving medications is supported by consistently high-quality intermediates.