In the realm of organic chemistry and particularly in peptide synthesis, the precise handling of amino acids with reactive side chains is crucial. Histidine, with its imidazole ring, is one such amino acid that requires careful protection to ensure successful peptide chain construction. Protected histidine derivatives, with N-alpha, N-im-bis-Boc-L-histidine (Boc-His(Boc)-OH) at the forefront, are indispensable tools for achieving this goal. This derivative, identified by CAS 20866-46-0, offers a robust solution for researchers and manufacturers.

The imidazole moiety of histidine is amphoteric and can participate in various side reactions during peptide synthesis, including alkylation, acylation, and metal coordination, if left unprotected. The tert-butoxycarbonyl (Boc) group is an effective protecting group for both the alpha-amino and the imidazole nitrogen in histidine. By employing Boc-His(Boc)-OH, chemists can effectively shield these reactive sites, preventing premature or incorrect couplings. This ensures that the histidine residue is incorporated into the peptide sequence only when intended, thus maintaining the fidelity and yield of the synthesized peptide. This level of control is vital whether one is looking to buy Boc-His(Boc)-OH for small-scale laboratory experiments or for larger manufacturing runs.

The availability of high-quality Boc-His(Boc)-OH from reliable peptide synthesis reagents suppliers is a critical factor for researchers. When seeking this compound, understanding its CAS 20866-46-0 is essential for proper identification. Companies like NINGBO INNO PHARMCHEM CO.,LTD. specialize in providing these vital chemical intermediates. They ensure that the Boc-His(Boc)-OH they supply meets high purity standards, which is non-negotiable for complex syntheses where even minute impurities can lead to significant downstream problems. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supporting the scientific community with top-tier chemical building blocks.

The widespread use of Boc-His(Boc)-OH underscores its importance in modern peptide synthesis. It facilitates the creation of biologically active peptides, which are crucial for developing new pharmaceuticals, diagnostics, and research probes. As the field advances, the demand for reliable and well-protected amino acid derivatives like Boc-His(Boc)-OH will continue to grow, solidifying its position as a key component in the chemical synthesis toolkit. NINGBO INNO PHARMCHEM CO.,LTD. remains a steadfast partner in this endeavor.