Fmoc-Asp(OtBu)-OH (CAS 71989-14-5) represents a critical component in modern chemical synthesis, particularly within the fields of peptide chemistry and pharmaceutical development. NINGBO INNO PHARMCHEM CO.,LTD. specializes in the production and supply of this vital amino acid derivative, understanding its importance as a versatile building block. This article delves into its synthesis pathways and the diverse applications that make it indispensable for researchers and manufacturers worldwide.

The synthesis of Fmoc-Asp(OtBu)-OH typically involves the protection of L-aspartic acid. A common method is the reaction of L-aspartic acid 4-tert-butyl ester with 9-fluorenylmethyl chloroformate. This process selectively introduces the Fmoc protecting group onto the alpha-amino group, while the tert-butyl ester protects the beta-carboxyl group. The resulting compound, Fmoc-Asp(OtBu)-OH, is a white to light yellow crystalline powder, characterized by a melting point of approximately 148-150 °C. Ensuring high purity during synthesis is crucial, as it directly impacts the success of subsequent applications. Companies often seek to purchase high-purity grades for demanding synthetic protocols.

The primary application of Fmoc-Asp(OtBu)-OH lies in solid-phase peptide synthesis (SPPS). In this technique, the protected amino acid is sequentially coupled to a growing peptide chain immobilized on a solid support. The Fmoc group is then removed under mild basic conditions, allowing the next Fmoc-protected amino acid to be added. This iterative process enables the synthesis of complex peptides with high precision and efficiency. The availability of quality Fmoc-Asp(OtBu)-OH from suppliers like NINGBO INNO PHARMCHEM CO.,LTD. ensures that researchers can reliably produce peptides for various research purposes, including drug discovery and biochemical studies. Understanding the current price and market availability is vital for procurement planning.

Beyond peptide synthesis, Fmoc-Asp(OtBu)-OH also finds utility in other areas of organic chemistry. It can serve as a chiral building block for the synthesis of complex organic molecules and intermediates for pharmaceutical production. The specific arrangement of functional groups and the inherent chirality of the molecule make it a valuable tool for chemists designing sophisticated synthetic routes. As the demand for advanced chemical compounds grows, the role of Fmoc-Asp(OtBu)-OH as a key intermediate continues to expand, driving innovation across multiple scientific disciplines. Securing a consistent supply at competitive pricing remains a priority for many research institutions and chemical companies.