Understanding 4-Carboxy-3-fluorophenylboronic Acid: Properties and Synthesis Applications
4-Carboxy-3-fluorophenylboronic acid, identified by CAS number 120153-08-4, is a specialized organic compound that plays a crucial role in modern chemical synthesis, particularly within the pharmaceutical sector. This article aims to provide a comprehensive overview of its chemical properties, common applications, and the advantages of sourcing it from reliable manufacturers.
Chemically, 4-Carboxy-3-fluorophenylboronic acid possesses the molecular formula C7H6BFO4 and a molecular weight of approximately 183.93 g/mol. Its physical appearance is typically described as a white powder, with a melting point ranging from 236-240°C. The presence of both a carboxylic acid group (-COOH) and a boronic acid group (-B(OH)2) on the fluorinated phenyl ring makes it a bifunctional molecule with diverse reactivity. This duality is highly valued in organic chemistry, enabling its use in various coupling reactions and as a versatile building block. A key property is its solubility in water, which facilitates its integration into aqueous or mixed solvent reaction systems, simplifying many synthetic procedures.
The utility of 4-Carboxy-3-fluorophenylboronic acid is most prominently observed in its role as a pharmaceutical intermediate. It is frequently employed in Suzuki-Miyaura cross-coupling reactions, where it reacts with organohalides or pseudohalides to form new carbon-carbon bonds. This reaction is fundamental in the synthesis of many complex organic molecules, including active pharmaceutical ingredients (APIs). The fluorine atom on the phenyl ring can enhance the pharmacokinetic properties of the resulting drug molecules, such as increasing lipophilicity and metabolic stability. For researchers and chemists looking to buy this compound, understanding its specifications, such as a purity of ≥98.0%, ensures predictable and efficient reaction outcomes. Many suppliers offer this chemical, but choosing a manufacturer in China known for quality control, like NINGBO INNO PHARMCHEM CO.,LTD., is advisable for consistent results.
The ease with which this compound can be functionalized makes it an attractive choice for creating diverse chemical libraries and for the targeted synthesis of compounds with specific biological activities. Whether it's for creating novel anti-cancer agents, antivirals, or other therapeutic compounds, 4-Carboxy-3-fluorophenylboronic acid provides a robust platform. For those in need of this essential chemical, exploring purchase options from reputable suppliers is the next step. The ability to buy this high-grade intermediate directly from manufacturers in China offers a significant advantage in terms of cost-effectiveness and supply chain reliability.
Perspectives & Insights
Future Origin 2025
“It is frequently employed in Suzuki-Miyaura cross-coupling reactions, where it reacts with organohalides or pseudohalides to form new carbon-carbon bonds.”
Core Analyst 01
“This reaction is fundamental in the synthesis of many complex organic molecules, including active pharmaceutical ingredients (APIs).”
Silicon Seeker One
“The fluorine atom on the phenyl ring can enhance the pharmacokinetic properties of the resulting drug molecules, such as increasing lipophilicity and metabolic stability.”