For professionals engaged in chemical synthesis and research, a thorough understanding of the properties and safe handling of chemical intermediates is crucial. This article from NINGBO INNO PHARMCHEM CO.,LTD. focuses on 2-chloro-3-fluoroaniline (CAS 21397-08-0), detailing its key characteristics and essential safety precautions.

2-Chloro-3-fluoroaniline is identified by its CAS number 21397-08-0, with a molecular formula of C6H5ClFN and a molecular weight of 145.56. Physically, it is often described as a powder, though some sources note it can appear as a liquid with a pale color. Key physical properties include a boiling point of approximately 210.3±20.0 °C and a density of around 1.349±0.06 g/cm³. These parameters are important for process design and optimization in chemical manufacturing.

The chemical reactivity of 2-chloro-3-fluoroaniline is largely influenced by the electron-withdrawing effects of the halogen substituents and the nucleophilic nature of the amino group. This makes it a versatile intermediate for a wide range of organic reactions. As a key component in the synthesis of 2-chloro-3-fluoroaniline, its precursors and reaction conditions are carefully managed to ensure the final product's quality and purity, which is essential for its intended applications in pharmaceuticals and fine chemical synthesis.

Safety is paramount when working with any chemical compound. 2-Chloro-3-fluoroaniline is generally classified with hazard statements such as 'Causes skin irritation', 'Causes serious eye irritation', and 'May cause respiratory irritation'. Therefore, appropriate personal protective equipment (PPE) is essential. This includes chemical-resistant gloves, safety goggles or a face shield, and protective clothing. Work should be conducted in a well-ventilated area, preferably under a fume hood, to avoid inhalation of dust or vapors. Proper storage, typically under an inert gas like nitrogen or argon at refrigerated temperatures (2–8 °C), is also recommended to maintain its stability and purity.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality chemical products along with comprehensive safety data. Our aim is to support researchers and industrial chemists by supplying reliable intermediates like 2-chloro-3-fluoroaniline, backed by diligent quality control and safety information. By adhering to recommended handling and storage procedures, users can effectively and safely leverage this important chemical building block for their synthetic endeavors.