2-Chloro-3-fluoroaniline: Properties, Applications, and Synthesis of a Key Pharmaceutical Intermediate
Discover the critical role of this fluorinated aniline derivative in modern organic synthesis and pharmaceutical development.
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2-Chloro-3-fluoroaniline
2-Chloro-3-fluoroaniline (CAS: 21397-08-0) is a vital chemical intermediate, extensively utilized in the synthesis of advanced organic compounds and pharmaceutical agents. Its unique structure, featuring both chlorine and fluorine substituents on an aniline core, makes it a sought-after building block for targeted chemical transformations.
- Explore the detailed properties of 2-chloro-3-fluoroaniline, including its molecular formula C6H5ClFN and a molecular weight of 145.56, crucial for precise stoichiometric calculations in synthesis.
- Understand the synthesis of 2-chloro-3-fluoroaniline, which typically involves the reduction of its nitro precursor, providing insights into its manufacturing process.
- Learn about the various applications of 2-chloro-3-fluoroaniline as a key intermediate in pharmaceutical research and development, contributing to the creation of novel therapeutic compounds.
- Access essential safety information and handling guidelines for 2-chloro-3-fluoroaniline, ensuring safe laboratory and industrial practices.
Key Advantages
Versatile Synthesis Building Block
As a valuable organic synthesis building block, its dual halogenation allows for diverse reaction pathways, facilitating complex molecular construction.
Crucial for Pharmaceutical Development
Its role as a pharmaceutical intermediate is underscored by its utility in synthesizing novel drug candidates, supporting the advancement of medicinal chemistry.
Enhanced Reactivity Profile
The presence of fluorine and chlorine atoms imparts specific electronic and steric properties, enhancing its reactivity and selectivity in chemical reactions.
Key Applications
Pharmaceutical Synthesis
Used as a critical precursor in the development of various active pharmaceutical ingredients (APIs) and therapeutic agents, contributing to the fine chemical intermediates sector.
Organic Synthesis
Serves as a versatile reagent in organic synthesis, enabling the construction of complex molecules through various coupling and substitution reactions.
Chemical Research
Its unique structural features make it an important compound for academic and industrial research, exploring new synthetic methodologies and material properties.
Fluorinated Chemical Development
Essential for the synthesis of fluorinated organic compounds, which are increasingly important in materials science and pharmaceuticals.