Diatrizoic Acid Dihydrate (CAS 50978-11-5) is a compound of significant importance in both clinical diagnostics and scientific research. As a derivative of benzoic acid, it is characterized by its high iodine content, which makes it an effective radiopaque agent. This article aims to provide a comprehensive overview for healthcare professionals and researchers, detailing its properties, applications, and essential considerations for its use.

Chemically, Diatrizoic Acid Dihydrate is known for its molecular formula C11H13I3N2O6 and a molecular weight of 649.94. Its appearance can range from a white to yellow or green powder, block, or even a transparent liquid, depending on its preparation and purity. The compound is very slightly soluble in water and ethanol, but readily soluble in alkali metal hydroxides, a property that influences its formulation into injectable solutions.

The primary application of Diatrizoic Acid Dihydrate is as a diagnostic drug and contrast agent. It is a critical component in the preparation of injectable forms like sodium diatrizoate and diatrizoate meglumine. These formulations are extensively used in various angiography procedures, including those targeting the urinary tract, cardiovascular system, cerebrovascular pathways, and peripheral vasculature. For gastrointestinal imaging, it is particularly noted for its utility in patients with barium allergies, providing a safe and effective alternative for X-ray examination of the GI tract. Professionals often consider its use for contrast agent for CT scan procedures due to its reliable performance.

Beyond medical imaging, Diatrizoic Acid Dihydrate also serves valuable purposes in histology. In laboratory settings, it assists in the detailed examination of cellular structures and tissue samples, enhancing the clarity needed for accurate analysis. This application is critical for researchers studying disease pathology or the effects of new compounds on biological tissues. The reliable performance of diatrizoic acid for histology makes it a preferred choice for many research protocols.

While generally safe when used as directed, it's important to note certain precautions. Diatrizoate is minimally absorbed from the intestines, but its high osmolarity can draw water into the intestines, potentially causing dehydration in vulnerable individuals, especially infants with low plasma volume. Allergic reactions to iodine are a key consideration, and professionals must be aware of the potential for adverse effects. For those involved in pharmaceutical development, understanding the properties of diatrizoic acid dihydrate is crucial for creating safe and effective diagnostic tools.

NINGBO INNO PHARMCHEM CO.,LTD. provides high-quality Diatrizoic Acid Dihydrate, ensuring that medical professionals and researchers have access to a dependable source for their critical needs. Whether for diagnostic angiography or detailed histological studies, this compound remains an essential element in modern healthcare and scientific advancement.