Copovidone VA64: The Versatile Pharmaceutical Excipient
Unlock superior tablet binding, film-forming, and controlled release capabilities with Copovidone VA64.
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Copovidone VA64
Copovidone VA64 is a highly versatile synthetic random copolymer, recognized for its exceptional performance as a pharmaceutical excipient. Its primary value lies in its ability to act as an effective binder for tablets, facilitating both wet granulation and direct compression processes. Furthermore, its film-forming properties are crucial for tablet coatings, enhancing stability and aesthetics. The material's utility extends to creating matrix systems for amorphous solid dispersions via methods like hot melt extrusion, significantly improving the dissolution rates of poorly soluble active pharmaceutical ingredients. Its favorable characteristics, including good plasticity and reduced hygroscopicity compared to traditional binders, make it a preferred choice in demanding formulation environments.
- Explore the application of copovidone VA64 as a key pharmaceutical excipient for enhanced drug efficacy.
- Discover how copovidone VA64 excels as a binder, improving tablet hardness and reducing friability.
- Understand the role of copovidone VA64 in film-forming applications, offering better plasticity and moisture barrier properties.
- Learn about utilizing copovidone VA64 for controlled release formulations and amorphous solid dispersions through hot melt extrusion.
Key Advantages
Enhanced Binding Efficiency
Copovidone VA64 provides superior dry binding for direct compression and excels in wet granulation, offering excellent adhesion, elasticity, and hardness to tablets, making it a valuable binder for tablet manufacturing.
Superior Film-Forming Properties
As a film former, copovidone VA64 contributes to flexible and less hygroscopic films compared to homopolymers, which is beneficial for tablet coating and protecting sensitive ingredients.
Ideal for Controlled Release
The unique properties of copovidone VA64 make it an ideal matrix former for amorphous solid dispersions using techniques like hot melt extrusion, crucial for developing sustained-release formulations.
Key Applications
Pharmaceutical Formulations
As a pharmaceutical excipient, copovidone VA64 is widely used as a binder, film-former, and matrix former for tablets, capsules, and oral solid dosage forms to improve drug delivery and stability.
Cosmetics
In cosmetics, copovidone VA64 functions as a thickener, dispersant, lubricant, and film-forming agent in hair care products like hair sprays and lotions.
Adhesives
Copovidone VA64 can be used as a remoistenable adhesive and viscosity-enhancing agent in various adhesive applications, particularly for paper products.
Printing Inks
It serves as a protective colloid and viscosity-enhancing agent in the formulation of printing inks, contributing to their stability and application properties.