Unlocking Mirabegron Synthesis: The Role of (1R)-2-[2-(4-nitrophenyl)ethylamino]-1-phenylethanol
A critical pharmaceutical intermediate for overactive bladder treatments, essential for efficient API manufacturing.
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(1R)-2-[2-(4-nitrophenyl)ethylamino]-1-phenylethanol
This compound serves as a pivotal building block in the synthesis of Mirabegron, a widely used medication. Its unique structure, featuring a chiral center and a nitro group, makes it indispensable for creating the final active pharmaceutical ingredient (API).
- Discover the synthesis pathway of Mirabegron, emphasizing the critical role of this nitro group reduction intermediate. Understanding the Mirabegron intermediate process is key to efficient drug production.
- Explore the importance of chiral synthesis in API manufacturing, highlighting how this compound contributes to producing enantiomerically pure drugs. Chiral synthesis of APIs requires precise building blocks.
- Learn about the applications of this compound as a pharmaceutical intermediate, directly impacting the development of treatments for overactive bladder. This is a vital component for pharmaceutical intermediates.
- Gain insights into the chemical properties and specifications crucial for its industrial use, ensuring quality and efficacy in the final pharmaceutical product. High purity is vital for API manufacturing.
Advantages of Using This Intermediate
Streamlined Synthesis
Utilizing this compound as a key building block significantly simplifies the pharmaceutical synthesis of Mirabegron, reducing reaction steps and improving overall yield. This is a crucial aspect of API manufacturing.
Enantiomeric Purity
The compound's inherent chirality is essential for producing the correct enantiomer of Mirabegron, a requirement for its therapeutic efficacy and safety in treating overactive bladder. This contributes to precise chiral synthesis of APIs.
Quality Assurance
With a high assay purity of ≥98.0%, it meets stringent pharmaceutical standards, ensuring the quality and consistency of the final drug product, a hallmark of reliable specialty chemical intermediates for pharma.
Key Applications
Mirabegron Manufacturing
This compound is directly used in the multi-step synthesis of Mirabegron, a drug targeting the beta-3 adrenergic receptor for overactive bladder. It's a cornerstone in pharmaceutical intermediates production.
API Development
Its utility extends to the broader field of Active Pharmaceutical Ingredient (API) development, serving as a versatile intermediate for other complex molecules requiring similar structural motifs. This highlights its value in API manufacturing.
Chiral Chemistry Research
Researchers in chiral chemistry utilize this compound to explore novel synthetic routes and methodologies for creating enantiomerically pure pharmaceuticals. It's a prime example for chiral synthesis of APIs.
Organic Synthesis
Beyond Mirabegron, it serves as a valuable reagent in various organic synthesis projects where the specific arrangement of its functional groups is beneficial for creating target molecules. This is central to organic synthesis pathways.
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