Sodium 2-Iodoacetate: A Key Intermediate for Advanced Chemical Synthesis
Discover the essential properties and diverse applications of this vital chemical compound.
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Sodium 2-Iodoacetate
Sodium 2-Iodoacetate (CAS: 305-53-3) is a critical fine chemical intermediate valued for its role in complex chemical synthesis and biochemical research. Its primary utility lies in its ability to act as a reagent for modifying cysteine residues in proteins, a fundamental process in protein sequencing and structural analysis.
- Facilitating Protein Modification: Leveraging its reactivity, sodium 2-iodoacetate is instrumental in protein modification, particularly for preventing the oxidation of -SH sidechains during processes like protein sequencing.
- Inducing Osteoarthritis Models: Researchers utilize sodium 2-iodoacetate to create animal models of osteoarthritis, mimicking both the symptoms and histopathology of the human disease, aiding in the testing of new therapeutic agents.
- Ensuring High Purity: With assay rates of ≥99.5%, this compound is ideal for applications demanding stringent purity standards, contributing to reliable and reproducible experimental outcomes.
- Versatile Pharmaceutical Intermediate: As a key pharmaceutical intermediate, it plays a significant role in the synthesis pathways of various active pharmaceutical ingredients and diagnostic reagents.
Advantages Provided by the Product
Precision in Protein Chemistry
The precise modification of cysteine residues is crucial for understanding protein structure and function. Sodium 2-Iodoacetate provides the necessary specificity for these critical biochemical reactions, supporting advancements in protein modification research.
Advancing Medical Research
By enabling the creation of accurate osteoarthritis models, this compound aids in the development and testing of novel treatments, contributing significantly to the field of regenerative medicine and drug discovery.
Reliability in Synthesis
Its high purity and consistent quality make it a reliable building block for complex organic syntheses, ensuring predictable reaction outcomes for pharmaceutical and fine chemical manufacturers seeking dependable pharmaceutical intermediates.
Key Applications
Protein Sequencing and Analysis
Essential for preventing sidechain oxidation, supporting accurate amino acid sequencing and protein structural studies, a core aspect of protein modification.
Osteoarthritis Disease Modeling
Used to create reliable in vivo models that mimic human osteoarthritis, crucial for testing potential chondroprotective agents and diagnostic imaging techniques.
Pharmaceutical Synthesis
Serves as a vital building block and reagent in the multi-step synthesis of various pharmaceutical compounds, highlighting its role as a key pharmaceutical intermediate.
Biochemical Reagent
A fundamental reagent in biochemical laboratories for a range of studies focusing on enzyme kinetics, protein-ligand interactions, and metabolic pathway analysis.