Bempedoic Acid: A Novel ATP Citrate Lyase Inhibitor for Cholesterol Management

The innovative solution for managing high cholesterol when statins are not an option.

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Key Advantages

Novel Mechanism

Bempedoic acid inhibits ATP citrate lyase (ACLY), a key enzyme in cholesterol synthesis, providing a novel approach distinct from statins.

Statin Intolerance Solution

This compound offers a vital therapeutic option for patients who experience adverse effects from statins, ensuring effective cholesterol lowering is still achievable.

Clinical Efficacy

Bempedoic acid clinical trials have demonstrated its safety and efficacy in reducing LDL cholesterol levels, supporting its role in cardiovascular health.

Key Applications

Hypercholesterolemia Treatment

Primarily used to manage high cholesterol levels in adults, particularly those with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease.

Cardiovascular Disease Management

By effectively lowering LDL cholesterol, it contributes to the broader management and prevention of cardiovascular events.

Statin-Alternative Therapy

Provides a crucial alternative for patients who are statin-intolerant or for whom statins are contraindicated, ensuring treatment continuity.

Adjunct Therapy

Can be used in combination with statins or other lipid-lowering therapies for patients needing further LDL-C reduction.