Gadobutrol CAS 138071-82-6: An Advanced MRI Contrast Agent for Enhanced Diagnostics
Discover the enhanced diagnostic capabilities of Gadobutrol, a leading MRI contrast agent, offering superior clarity and safety.
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Gadobutrol
Gadobutrol, identified by CAS number 138071-82-6, stands as a state-of-the-art MRI contrast agent. Its unique formulation as a nonionic, macrocyclic gadolinium chelate provides exceptionally high relaxivity and is available at a 1.0 M concentration. This allows for a more concentrated bolus and enhanced signal-to-noise ratios, significantly improving the visualization of anatomical structures and pathologies in Magnetic Resonance Imaging (MRI) and Magnetic Resonance Angiography (MRA). Its robust stability and favorable pharmacokinetic profile, characterized by rapid renal elimination of the unchanged drug, contribute to its excellent safety and tolerability profile.
- Leveraging 1.0 M concentration, Gadobutrol offers superior diagnostic efficacy in CNS imaging compared to lower concentration agents, aiding in precise lesion detection.
- The high relaxivity of this gadolinium-based contrast agent ensures improved image quality in MRA, crucial for diagnosing vascular abnormalities and arterial diseases.
- Gadobutrol demonstrates a well-established safety profile with a low incidence of adverse reactions, making it a reliable choice for a broad patient population, including pediatric cases.
- Its application extends to various body regions, providing enhanced visualization for liver, kidney, and other organ imaging, thereby supporting more accurate diagnoses.
Key Advantages
Enhanced Diagnostic Clarity
The high relaxivity and 1.0 M concentration of Gadobutrol significantly improve the signal-to-noise ratio, leading to clearer and more detailed MRI images, which is vital for accurate disease diagnosis.
Proven Safety Profile
Extensive clinical studies and post-marketing surveillance indicate that Gadobutrol is well-tolerated, with a low incidence of adverse reactions, including a low risk of NSF, a serious condition associated with some GBCAs.
Broad Clinical Utility
From CNS imaging to MRA and general body scans, Gadobutrol proves effective across a wide range of medical applications, providing consistent diagnostic performance.
Key Applications
Central Nervous System (CNS) Imaging
Gadobutrol enhances the visualization of brain and spinal cord lesions, assisting in the diagnosis of conditions like tumors, inflammation, and vascular abnormalities.
Magnetic Resonance Angiography (MRA)
Used to evaluate known or suspected supra-aortic or renal artery disease, providing detailed images of blood vessels for accurate assessment.
Body and Vessel Imaging
Effectively used for contrast-enhanced MRI of the liver, kidneys, heart, and other organs, improving lesion detection and characterization.
Pediatric Imaging
Demonstrates efficacy and safety in pediatric patients aged 2 years and above, making it a valuable tool for younger populations requiring diagnostic imaging.