In the intricate landscape of cellular signaling, the P2X7 receptor stands out as a critical player in various physiological and pathological processes. Acid Blue 90, also known as Coomassie Brilliant Blue G-250 (CAS 6104-58-1) and more specifically referred to as Brilliant Blue G (BBG) in pharmacological contexts, has emerged as a key tool for researchers investigating this receptor. Its ability to selectively inhibit the P2X7 channel makes it invaluable in neuroscience, immunology, and pain research. As a chemical supplier, we provide high-quality Acid Blue 90 for these advanced research applications.

What is the P2X7 Receptor?

P2X receptors are a family of ligand-gated ion channels that are activated by extracellular ATP. There are seven known subtypes (P2X1-P2X7). The P2X7 receptor, in particular, is known for its unique activation properties. When exposed to high concentrations of ATP, it not only opens a pore permeable to small cations but can also undergo further conformational changes to form a larger pore that allows the passage of larger molecules, including ions and even cell death mediators. This receptor is widely expressed in the immune system, particularly on immune cells like macrophages and microglia, as well as in the nervous system, playing roles in neuroinflammation, pain signaling, and neuronal death.

Brilliant Blue G as a P2X7 Antagonist

Brilliant Blue G has been identified as a potent and relatively selective antagonist of the P2X7 receptor. Research has shown that BBG can inhibit both rat and human P2X7 receptors with distinct IC50 values, suggesting a specific binding interaction. Its mechanism of action involves non-competitive inhibition, meaning it binds to a site on the receptor different from the ATP binding site, thereby modulating its function. This inhibitory action makes BBG an essential reagent for researchers looking to study the consequences of P2X7 receptor activation or to explore its role in disease models.

Significance in Research and Therapeutic Potential

The ability of Brilliant Blue G to block P2X7 activity has profound implications. In neuroscience, BBG is used to investigate the receptor's role in conditions like ischemia-reperfusion injury, Alzheimer's disease, spinal cord injury, and sensory neuropathies. By blocking P2X7 receptors, researchers can determine their contribution to these pathologies and potentially explore therapeutic strategies. For instance, inhibiting P2X7 signaling might reduce neuroinflammation or protect neurons from excitotoxicity. For scientists working in these areas, the ability to buy Acid Blue 90 from a reliable supplier is crucial for consistent experimental outcomes.

Sourcing High-Purity BBG for Research

When procuring Brilliant Blue G for pharmacological studies, ensuring its purity and correct identification is paramount. Acid Blue 90 from a trusted manufacturer offers the necessary quality for accurate and reproducible results. We provide high-grade Acid Blue 90 (CAS 6104-58-1) suitable for biochemical and pharmacological research. If your work involves studying P2X7 receptors or related signaling pathways, consider us as your go-to supplier. Contact us today to discuss your needs and get a quote for this vital research chemical.