Afamelanotide, also known by its designation Melanotan I (MT-1) and identified by CAS number 75921-69-6, is a synthetic peptide that has garnered substantial attention for its role in enhancing the body's natural defense against UV radiation. As a potent analogue of alpha-melanocyte-stimulating hormone (α-MSH), its primary action is to stimulate melanocytes, the cells responsible for producing melanin, the pigment that colors our skin and hair.

The mechanism of Afamelanotide involves binding to the melanocortin 1 receptor (MC1R), a critical component in the regulation of melanogenesis – the process of melanin synthesis. By activating MC1R, Afamelanotide promotes increased melanin production, which in turn provides enhanced photoprotection. This capability is particularly significant for individuals diagnosed with Erythropoietic Protoporphyria (EPP), a rare condition causing extreme sensitivity to light. Research into afamelanotide for erythropoietic protoporphyria has demonstrated its efficacy in increasing pain-free exposure to sunlight, thereby improving the quality of life for affected patients.

Typically available as a high-purity lyophilized powder, Afamelanotide is a valuable asset for researchers exploring its therapeutic potential. Understanding what is afamelanotide mt-1 provides insight into its function as a melanocortin receptor agonist. Current scientific endeavors are focused on deciphering precisely how does afamelanotide work in various biological contexts, including its potential effects on inflammation and DNA repair.

The applications of synthetic peptide afamelanotide are not limited to EPP. Its intrinsic photoprotective qualities are being investigated for broader use in skincare and the management of other light-sensitive dermatological conditions. The availability of afamelanotide mt-1 lyophilized powder facilitates this ongoing research, enabling scientists to delve deeper into its pharmacological profile.

NINGBO INNO PHARMCHEM CO.,LTD. plays a vital role in the scientific community by supplying high-quality research materials like Afamelanotide. By providing access to such advanced compounds, the company supports critical advancements in peptide science, contributing to the development of innovative solutions for skin health and the treatment of light-related disorders.