Understanding the detailed chemical properties and extensive applications of an API is fundamental for pharmaceutical formulators and procurement specialists. Enrofloxacin Hydrochloride (CAS 112732-17-9) is a potent fluoroquinolone antibacterial agent widely utilized in veterinary medicine. This article aims to provide a comprehensive overview of its chemical characteristics and its critical role in animal health, guiding buyers on its sourcing from reliable manufacturers.

Chemical Properties of Enrofloxacin Hydrochloride
Enrofloxacin Hydrochloride is the hydrochloride salt form of enrofloxacin. Its chemical name is 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-, hydrochloride (9CI). Key chemical properties include:

  • Molecular Formula: C19H22FN3O3.HCl
  • Molecular Weight: 395.86
  • Appearance: White or almost white crystalline powder. This physical characteristic is important for visual quality checks by buyers.
  • Solubility: It exhibits slight solubility in methanol and water, which is relevant for formulation development and analytical testing.
  • Stability: The compound is generally stable under standard conditions but is noted to be hygroscopic, meaning it can absorb moisture from the air, requiring appropriate storage conditions (e.g., tightly closed containers in a dry place).
  • Melting Point: Typically reported as >285°C with decomposition, indicating high thermal stability.

These properties are crucial for formulators to consider when developing dosage forms, ensuring the stability and efficacy of the final veterinary drug product.

Veterinary Applications and Benefits
Enrofloxacin Hydrochloride is a cornerstone in veterinary antimicrobial therapy due to its broad-spectrum activity and favorable pharmacokinetics. Its primary applications include:

  • Treatment of Bacterial Infections: It is highly effective against a wide range of Gram-negative and Gram-positive bacteria, as well as mycoplasmas, making it useful for treating common animal ailments. This includes respiratory tract infections, gastrointestinal infections, urinary tract infections, and skin/wound infections in various animal species.
  • Livestock and Poultry Health: In intensive farming, it is used to manage and prevent diseases like pneumonia, bronchitis, colibacillosis, and salmonellosis, contributing to animal productivity and welfare.
  • Aquaculture: It plays a role in treating bacterial infections in farmed fish and shrimp.
  • Companion Animal Care: Enrofloxacin Hydrochloride is commonly prescribed for pets to treat infections such as otitis and skin conditions.

The benefits of using Enrofloxacin Hydrochloride include its broad spectrum of activity, rapid absorption leading to quick therapeutic levels, and excellent penetration into target tissues, ensuring efficacy even in deep-seated infections. Its long half-life also allows for less frequent dosing, improving animal handling compliance.

Procurement Considerations from Manufacturers
When looking to buy Enrofloxacin Hydrochloride, it is vital to source from reliable manufacturers. Suppliers like NINGBO INNO PHARMCHEM CO.,LTD. offer this API, ensuring high purity and adherence to pharmacopoeia standards. Buyers should always request detailed technical data sheets and Certificates of Analysis to confirm product quality, check impurity levels, and verify manufacturing compliance. Understanding the price range and competitive offerings from Chinese manufacturers is also key to efficient procurement.

Conclusion
Enrofloxacin Hydrochloride is a critical API for the veterinary pharmaceutical industry, offering potent antibacterial action and versatile applications. A thorough understanding of its chemical properties and a strategic approach to sourcing from reputable manufacturers are essential for developing effective and safe animal health products. Ensuring the quality and consistency of this API through careful supplier selection is a key determinant of success in the competitive veterinary drug market.