Afamelanotide, also recognized as Melanotan I (MT-1), is a synthetic peptide that has emerged as a significant compound in dermatological research, primarily for its impact on melanin synthesis and photoprotection. As a derivative of alpha-melanocyte-stimulating hormone (α-MSH), its biological activity centers on stimulating melanocytes, the cells responsible for producing melanin, the pigment that determines skin, hair, and eye color.

The key to Afamelanotide's function lies in its potent binding affinity to the melanocortin 1 receptor (MC1R). This interaction is crucial because MC1R signaling is the primary pathway that initiates melanogenesis – the complex process of melanin production. By activating this pathway, Afamelanotide leads to an increase in melanin levels within the skin. This heightened melanin concentration provides a natural shield against the damaging effects of ultraviolet (UV) radiation, thus offering enhanced photoprotection. This is particularly relevant for conditions such as Erythropoietic Protoporphyria (EPP), where the body's ability to produce sufficient melanin is compromised, leading to extreme sun sensitivity.

In clinical settings, Afamelanotide is often administered in its lyophilized powder form, ensuring stability and potency for research and therapeutic applications. Understanding what is afamelanotide mt-1 is essential for appreciating its role in medical research. Its CAS number, 75921-69-6, specifically identifies this chemical entity.

Research on afamelanotide for erythropoietic protoporphyria has shown that it can significantly improve patients' tolerance to sunlight, allowing for longer periods of pain-free exposure. This remarkable effect stems directly from its ability to bolster the skin's natural defense mechanisms. Beyond EPP, scientists are investigating the potential of synthetic peptide afamelanotide for broader photoprotective benefits and the treatment of other light-induced skin conditions. The question of how does afamelanotide work in these diverse applications is a focal point of ongoing studies.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing researchers with high-quality, reliable compounds like afamelanotide mt-1 lyophilized powder. By supplying such advanced materials, the company supports critical research aimed at developing new treatments and enhancing our understanding of peptide-based solutions for skin health and disease management.