In the intricate world of fine chemicals, understanding both the synthesis and application of key intermediates is crucial for chemists and researchers. Ethanol, 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxy)]bis-, 1,1'-diacetate, identified by its CAS number 19224-29-4, is one such compound that holds significant value across various industries. This article provides a detailed look into its preparation, characterization, and application spectrum, emphasizing its role as a versatile chemical building block.

Synthetic Routes to CAS 19224-29-4

The efficient synthesis of Ethanol, 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxy)]bis-, 1,1'-diacetate typically involves a multi-step process, often starting from readily available precursors. A common pathway includes:

  1. Epoxidation of Bisphenol A Derivative: The process often begins with a derivative of Bisphenol A, which undergoes reaction with ethylene oxide. This critical step introduces the ethoxy linkages necessary for subsequent functionalization. Precise control over reaction conditions, including temperature and catalyst selection, is essential to achieve high yields of the intermediate diol.
  2. Acetylation: The diol intermediate is then subjected to acetylation. This is commonly achieved using acetic anhydride in the presence of an acidic catalyst, such as sulfuric acid, or milder catalytic systems for better control. The goal is to replace the hydroxyl groups with acetate functionalities, leading to the final diacetate product. Optimization of reagent stoichiometry, reaction time, and temperature is vital to minimize byproduct formation and maximize the yield of the desired compound.

For industrial-scale production, continuous-flow reactors are often employed to enhance efficiency, scalability, and product consistency. The selection of catalysts, such as immobilized ion-exchange resins, further contributes to sustainable and efficient manufacturing.

Characterization and Quality Assurance

Ensuring the high purity (≥99%) of CAS 19224-29-4 is paramount for its end-use applications. Standard characterization techniques employed by manufacturers include:

  • Spectroscopic Methods: Nuclear Magnetic Resonance (NMR) spectroscopy (¹H NMR and ¹³C NMR) is used to confirm the molecular structure and identify functional groups. Fourier-Transform Infrared (FT-IR) spectroscopy helps in verifying the presence of key functional groups like ester carbonyls (C=O).
  • Chromatographic Techniques: High-Performance Liquid Chromatography (HPLC) is widely used to assess the purity of the compound and quantify any impurities. Gas Chromatography (GC) can also be employed depending on the volatility and stability of the compound.
  • Mass Spectrometry (MS): MS is used to confirm the molecular weight and provide further structural information.

Diverse Applications of a Versatile Intermediate

The unique chemical structure of Ethanol, 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxy)]bis-, 1,1'-diacetate opens doors to a wide array of applications:

  • Pharmaceuticals: It serves as a vital intermediate in the synthesis of complex APIs and is integral to the development of advanced drug delivery systems.
  • Materials Science: Its use as a monomer or precursor in polymer production, including epoxy resins, coatings, and adhesives, is notable for enhancing material properties like thermal stability and adhesion.
  • Diagnostics: Its high purity makes it a suitable component for diagnostic reagents.

For researchers and manufacturers seeking a reliable supplier for this critical intermediate, NINGBO INNO PHARMCHEM CO.,LTD. offers high-quality CAS 19224-29-4. Our commitment to rigorous synthesis and quality control ensures you receive a product that meets your demanding specifications. Contact us to learn more about purchasing this versatile chemical.