In the dynamic field of pharmaceutical research, understanding the mechanisms of action for key compounds is paramount. Farnesyl transferase inhibitors (FTIs) represent a class of molecules that have garnered significant attention for their potential therapeutic applications, particularly in oncology and rare genetic disorders. Among these, Lonafarnib, identified by CAS number 193275-84-2, stands out as a critical research chemical. As a leading manufacturer and supplier of high-quality pharmaceutical intermediates in China, we aim to equip researchers with the knowledge and materials they need to advance their studies.

What is Farnesyl Transferase?

Farnesyl transferase (FTase) is an enzyme that plays a vital role in a cellular process called farnesylation. This process involves the attachment of a farnesyl group (a type of lipid) to specific proteins, a modification crucial for their proper function and localization within the cell. Many proteins involved in cell signaling pathways, including Ras proteins, undergo farnesylation. These pathways regulate cell growth, proliferation, and survival. Aberrant signaling mediated by mutated Ras proteins is a common hallmark of many cancers, making FTase a compelling target for therapeutic intervention.

Lonafarnib: A Potent FTase Inhibitor for Research

Lonafarnib (CAS 193275-84-2) is a selective, non-peptidomimetic competitive inhibitor of farnesyl transferase. Its mechanism of action involves blocking the farnesylation of proteins like Ras, thereby disrupting the signaling cascades that drive cancer cell proliferation. Beyond its role in oncology, Lonafarnib has also shown promise in research related to Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic disorder characterized by rapid premature aging, where farnesyl protein accumulation is implicated. For researchers exploring these complex biological processes, securing a reliable supply of high-purity Lonafarnib is essential.

Why Choose a Trusted Manufacturer and Supplier?

When conducting critical research, the quality and consistency of your chemical reagents directly impact the validity and reproducibility of your results. As a dedicated manufacturer and supplier of pharmaceutical chemicals in China, we prioritize stringent quality control measures to ensure our Lonafarnib meets the highest purity standards (≥99%). This commitment guarantees that your experiments, whether investigating novel anticancer agents or understanding rare disease mechanisms, are based on reliable materials. Furthermore, by sourcing directly from us, you benefit from competitive pricing and a stable supply chain, allowing you to focus on your scientific objectives without procurement concerns. For those looking to buy Lonafarnib or inquire about its price, connecting with a reputable manufacturer in China ensures both quality and cost-effectiveness.

We understand the importance of providing researchers with the tools they need to succeed. By offering high-grade Lonafarnib and detailed product information, we aim to be your preferred partner in advancing pharmaceutical discovery and development. If you are seeking a reliable supplier for your research needs, please do not hesitate to contact us for a quote or sample.