For chemists and material scientists, understanding the synthesis and inherent properties of key chemical intermediates is fundamental to driving innovation. 2-Amino-3-nitrophenol (CAS 603-85-0) is a prime example of such a compound, serving as a crucial building block in various industrial and research applications. This article provides an in-depth look at its synthesis, physical and chemical properties, and its significance as a readily available intermediate from trusted manufacturers.

Synthesis Pathways for 2-Amino-3-nitrophenol

The preparation of 2-Amino-3-nitrophenol (CAS 603-85-0) typically involves the selective reduction of a precursor molecule containing nitro and amino functionalities, or the nitration of an amino phenol. One common method involves the reduction of 2-amino-3-nitrobenzoic acid or similar nitro-substituted aminophenols. Another route might involve the nitration of 2-aminophenol under controlled conditions, followed by purification. For industrial-scale production, manufacturers optimize these processes to ensure high yields, purity, and cost-effectiveness. The goal is to produce a reliable brown-red powder with a purity often exceeding 99%, ready for use in downstream applications.

Key Physico-Chemical Properties

Understanding the properties of 2-Amino-3-nitrophenol is crucial for its effective application:

  • Appearance: It is typically described as a brown-red powder or crystalline solid.
  • Melting Point: The literature commonly cites a melting point in the range of 212-213 °C, indicating its solid state at room temperature and good thermal stability for many processes.
  • Solubility: It exhibits slight solubility in water but is generally more soluble in organic solvents, a common characteristic for many aromatic organic compounds.
  • Molecular Weight: Its molecular weight is approximately 154.12 g/mol (C6H6N2O3).
  • Reactivity: The presence of amine, nitro, and hydroxyl groups makes it reactive in various organic transformations, including diazotization, acylation, and nucleophilic substitution reactions.

Applications and Industrial Relevance

The primary industrial application of 2-Amino-3-nitrophenol is its role as an intermediate in the synthesis of dyes and pigments, particularly for yellow shades. It also finds use in custom organic synthesis projects where its specific functional groups are leveraged to create complex molecules for pharmaceuticals, agrochemicals, and research materials. Scientists often buy this compound for its utility as a building block in multi-step synthesis.

Sourcing 2-Amino-3-nitrophenol (CAS 603-85-0)

For researchers and formulators, sourcing this intermediate reliably is key. China hosts numerous manufacturers and suppliers specializing in fine chemicals and organic intermediates. When looking to purchase 2-Amino-3-nitrophenol, it is recommended to:

  • Verify Purity: Ensure the supplier guarantees a minimum purity of 99% and provides a Certificate of Analysis (CoA).
  • Compare Suppliers: Look at pricing, lead times, and customer service from multiple China-based chemical suppliers.
  • Request Samples: Test the product quality before committing to large-scale orders.

Conclusion

2-Amino-3-nitrophenol (CAS 603-85-0) remains a vital intermediate, appreciated for its well-defined synthesis pathways, characteristic properties, and broad utility in dye production and organic synthesis. By understanding its attributes and sourcing strategically from reliable manufacturers, professionals can effectively leverage this compound for their development and production needs.