N-Isopropylacrylamide (NIPAM), CAS 2210-25-5, is more than just a chemical compound; it's a cornerstone for researchers exploring stimuli-responsive materials. Its unique molecular architecture dictates its behavior in polymerization and its ability to impart remarkable thermosensitive properties to polymers. For scientists and research teams seeking to innovate with advanced materials, a deep understanding of NIPAM's scientific principles is invaluable. As a dedicated supplier and manufacturer, we provide high-quality NIPAM to fuel cutting-edge research worldwide.

At its core, N-Isopropylacrylamide is an amide of acrylic acid where the amide nitrogen is substituted with an isopropyl group. Its chemical formula is C6H11NO, and its structure features a vinyl group (C=C) adjacent to a carbonyl group (C=O), followed by the amide linkage to the isopropyl moiety. This structure is crucial. The vinyl group makes it readily polymerizable via free radical polymerization. The amide group contributes to polarity and hydrogen bonding capabilities, while the isopropyl group introduces hydrophobicity. This duality is the key to its LCST behavior.

The polymerization of N-Isopropylacrylamide typically proceeds via free radical mechanisms, initiated by compounds like azobisisobutyronitrile (AIBN) or peroxides. This process can be carried out in solution, emulsion, or suspension, allowing for the formation of polymers with different architectures and properties. Researchers often use techniques like inverse emulsion polymerization to synthesize poly(N-isopropylacrylamide) (pNIPAM) in nanoparticle or microgel forms. The precise control over polymerization conditions—temperature, initiator concentration, monomer-to-initiator ratio—allows scientists to tailor the molecular weight and particle size of the resulting pNIPAM, which directly influences its thermosensitive response and application performance.

The hallmark scientific significance of NIPAM lies in the LCST phenomenon of its polymer, pNIPAM. At temperatures below the LCST (around 33°C), the polymer chains are hydrated, forming expanded coils that are soluble in water. As the temperature increases above the LCST, the polymer chains dehydrate due to unfavorable hydrophobic interactions between the isopropyl groups and water. This leads to polymer aggregation and a sharp decrease in solubility, resulting in phase separation or a dramatic collapse of hydrogel networks. This reversible transition is a fascinating example of a polymer's response to an external stimulus.

This thermo-responsiveness has profound implications for scientific research and development. NIPAM-based hydrogels are being explored for applications such as micro-actuators, sensors, smart membranes for separation processes, and even as matrices for controlled release of biological molecules. Researchers studying protein folding, enzyme encapsulation, and biomaterial interactions often turn to NIPAM due to its biocompatibility and predictable phase transition. When considering these advanced applications, purchasing N-Isopropylacrylamide from a supplier that guarantees high purity and detailed scientific data is essential for experimental success.

As a supplier and manufacturer of N-Isopropylacrylamide (CAS 2210-25-5), we are dedicated to supporting the scientific community. We ensure our product meets the rigorous demands of chemical research, providing a consistent and reliable source for this important monomer. If your laboratory is investigating responsive polymers, hydrogels, or advanced biomaterials, we encourage you to buy NIPAM from us to ensure the quality and reproducibility of your scientific endeavors.