For chemists and product developers, understanding the specific properties and applications of key intermediates is fundamental to successful synthesis. 1,3-Dichloro-2,4-difluorobenzene (CAS 36556-37-3) stands out as a versatile building block with a broad spectrum of uses across industries. This article delves into its essential characteristics and highlights why it is a compound of interest for any forward-thinking laboratory.

Chemical Profile: The Fundamentals

1,3-Dichloro-2,4-difluorobenzene, with the CAS number 36556-37-3, presents a unique molecular structure. Its chemical formula is C6H2Cl2F2, and its molecular weight is approximately 182.98 g/mol. The compound is typically described as a clear, colorless liquid. Key physical properties that are vital for handling and reaction planning include:

  • Boiling Point: 180.6°C at 760 mmHg. This relatively high boiling point indicates good thermal stability under standard reaction conditions.
  • Flash Point: 64.4°C. This information is critical for safety assessments and dictates the necessary precautions during storage and use.
  • Density: 1.502 g/cm³.
  • Purity: Usually available with a minimum purity of 95%, ensuring it is suitable for most demanding synthesis applications.

These properties, combined with its chemical structure, make it an attractive starting material for a variety of transformations.

Versatile Applications Driving Innovation

The strategic placement of chlorine and fluorine atoms on the benzene ring of 1,3-Dichloro-2,4-difluorobenzene grants it distinct reactivity, leading to its widespread use:

  • Pharmaceutical Intermediates: In drug discovery and development, this compound serves as a crucial synthon. Its structure can be modified through nucleophilic aromatic substitution reactions to build complex molecules, forming the core of many potential drug candidates. Scientists often seek to buy this intermediate for its utility in constructing fluorinated pharmaceutical backbones.
  • Agrochemical Synthesis: The agrochemical industry relies on such intermediates to develop novel crop protection agents. The specific halogenation pattern can enhance the biological activity and environmental persistence of herbicides and pesticides.
  • Materials Science: For researchers in materials science, 1,3-Dichloro-2,4-difluorobenzene is a valuable component. It is used in the synthesis of liquid crystals, influencing their optical and thermal characteristics. Additionally, it finds application as a monomer in creating polymers with enhanced properties, such as improved thermal stability or flame resistance.
  • Organic Synthesis: More broadly, it is a versatile tool in general organic synthesis, allowing for the introduction of specific halogenated aromatic motifs into target molecules.

Securing Your Supply

For laboratories and manufacturing facilities, securing a reliable supply of 1,3-Dichloro-2,4-difluorobenzene is essential. Working with established manufacturers and suppliers, particularly those with a strong presence in global markets like China, can provide access to high-quality material at competitive prices. Many suppliers offer free samples, allowing researchers to test the product's suitability before making larger commitments. When inquiring, be sure to specify your purity requirements and desired quantities to receive accurate quotes.

By understanding its properties and applications, R&D scientists and formulators can effectively leverage 1,3-Dichloro-2,4-difluorobenzene to drive innovation and develop next-generation products.