1-Bromo-4-tert-butylbenzene, identified by CAS number 3972-65-4, is a significant chemical intermediate with a diverse range of applications in organic synthesis, pharmaceutical research, and material science. Its unique molecular structure, featuring a bromine atom and a tert-butyl group on a benzene ring, makes it a valuable building block for creating more complex organic molecules.

The synthesis of 1-Bromo-4-tert-butylbenzene typically involves the bromination of tert-butylbenzene. This process is often catalyzed by agents like iron powder, with careful control over reaction conditions to ensure high purity and yield. The resulting compound is a colorless to pale yellow liquid, characterized by a melting point of 13-16°C and a boiling point of 80-81°C at 2 mmHg. It exhibits good solubility in common organic solvents such as DMSO, benzene, and xylene, but is insoluble in water.

One of the primary uses of 1-Bromo-4-tert-butylbenzene is in organic synthesis, particularly in lithium-bromine exchange reactions. Reacting it with organolithium reagents like n-butyllithium or tert-butyllithium at low temperatures allows for the formation of (4-tert-butylphenyl)lithium. This organolithium intermediate is highly reactive and serves as a versatile synthon for introducing the 4-tert-butylphenyl group into various organic frameworks. This capability is crucial for synthesizing more complex molecules, including precursors for Suzuki coupling reactions like 4-tert-butylphenylboronic acid.

In the pharmaceutical sector, 1-Bromo-4-tert-butylbenzene acts as a key intermediate in the synthesis of specific pharmaceutical compounds and their analogs. For instance, it is utilized in the development of certain cannabinoid receptor agonists, such as analogs of CP-47,497 and CP-55,940, which are studied for their potential therapeutic effects. Researchers looking to buy high-quality intermediates for drug discovery can rely on consistent supply from established manufacturers.

Beyond pharmaceuticals, this compound finds application in material science. It can be incorporated into polymers or used as a precursor for developing advanced materials with tailored properties, contributing to innovation in electronics, coatings, and other industrial sectors. As a reliable manufacturer and supplier in China, we provide this critical chemical to support your material science research and development needs.

For businesses and researchers seeking to source 1-Bromo-4-tert-butylbenzene, manufacturers in China offer competitive pricing and consistent quality. When you need to purchase this vital chemical, looking for experienced suppliers who can provide technical support and ensure timely delivery is paramount. We, as a dedicated manufacturer, are committed to being your trusted partner, offering this essential intermediate to drive your projects forward. Inquire today to get a quote for your bulk requirements and experience the benefits of a stable supply chain.