1-Bromo-4-tert-butylbenzene, identified by CAS number 3972-65-4, is an important aryl bromide that serves as a versatile intermediate in a wide array of chemical applications. As a prominent manufacturer and supplier of fine chemicals, we provide this compound with guaranteed purity and reliability, essential for research and industrial processes. This article delves into its fundamental properties, key applications, and important handling considerations.

The chemical identity of 1-Bromo-4-tert-butylbenzene is characterized by its molecular formula C10H13Br and a molecular weight of 213.11 g/mol. Physically, it presents as a colorless to pale yellow liquid, with a melting point typically between 13-16°C and a boiling point of 80-81°C at 2 mmHg pressure (or 232°C at 760 mmHg). Its density is approximately 1.229 g/mL at 25°C, and it exhibits a refractive index (n20/D) of 1.519 or 1.533, depending on the source. Importantly, it is soluble in most organic solvents such as DMSO, ethers, and aromatic hydrocarbons, but insoluble in water. These properties are critical for chemists when planning reactions and purification strategies.

The synthetic utility of 1-Bromo-4-tert-butylbenzene is primarily anchored in its reactivity as an aryl halide. It is a preferred substrate for creating organometallic reagents through lithium-bromine exchange reactions, typically employing reagents like n-butyllithium or tert-butyllithium. The resultant organolithium compound, (4-tert-butylphenyl)lithium, is a powerful nucleophile used extensively in carbon-carbon bond forming reactions. This makes it invaluable for synthesizing complex organic molecules, including precursors for palladium-catalyzed cross-coupling reactions, such as the Suzuki coupling, which are foundational in modern synthetic chemistry. These reactions are pivotal for building pharmaceuticals and advanced materials.

In the pharmaceutical and life sciences sectors, 1-Bromo-4-tert-butylbenzene acts as a key intermediate for the synthesis of various biologically active compounds. It is used in the preparation of analogs of important drug targets, such as modulators of cannabinoid receptors. Researchers aiming to develop new therapeutic agents often buy this chemical to introduce the specific 4-tert-butylphenyl moiety into their target structures, which can influence lipophilicity, binding affinity, and metabolic stability.

When handling 1-Bromo-4-tert-butylbenzene, standard laboratory safety practices should be observed. It is classified as an irritant, with potential for skin, eye, and respiratory tract irritation. Therefore, appropriate personal protective equipment (PPE), including gloves, safety glasses, and lab coats, should be worn. Work should be conducted in a well-ventilated area, preferably a fume hood. Proper storage, typically in a cool, dry place away from incompatible materials and light, is also recommended to maintain its quality and stability.

As a leading manufacturer and supplier, we are committed to providing high-quality 1-Bromo-4-tert-butylbenzene to support your research and industrial needs. We encourage you to contact us for a quote for your bulk requirements and to discuss how our reliable supply can benefit your projects. Partner with us for your chemical sourcing needs.